caa a22 4500 475831292 CHVBK 20180406123840.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s100960000341 doi (NATIONALLICENCE)springer-10.1007/s100960000341 Enteric Fever and Other Extraintestinal Salmonellosis in University Hospital, Nottingham, UK, Between 1980 and 1997 [Elektronische Daten] [P. Ispahani, R. C. B. Slack]  The clinical spectrum of extraintestinal salmonellosis comprises enteric fever (typhoid and paratyphoid) and invasive infections due to nontyphoidal salmonellae. This study describes the clinical spectrum, management and outcome of all confirmed cases of extraintestinal salmonellosis in patients admitted to University Hospital, Nottingham, UK, between 1980 and 1997. There were 142 cases (children, 42; adults, 100) of extraintestinal salmonellosis, of which 38 (children, 20; adults, 18) were enteric fever, consisting of 21 cases of typhoid, 12 of paratyphoid A and five of paratyphoid B. All patients with typhoid and paratyphoid A fever were from Indian or Pakistani families and, except for two adults, all were considered to be previously fit. The outcome in patients with enteric fever was excellent, and there were no complications. Of the 104 patients (children, 22; adults, 82) with nontyphoidal salmonellosis, 69 were bacteraemic secondary to gastroenteritis, 10 were bacteraemic without an obvious focus of infection and 25 had focal infections. The three major sites of focal infections were meningitis in five infants, osteomyelitis in two children and three adults, and arterial infections in ten adults. The three most frequently isolated organisms were Salmonella enteritidis (40%), Salmonella typhimurium (25%) and Salmonella virchow (14%). Sixty-seven percent of these patients had underlying disease(s)/risk factors. In contrast to the outcome of enteric fever, there were 19 deaths (children, 2; adults, 17) in patients with nontyphoidal salmonellosis. Sixteen of the 17 adults who died were over the age of 60 years. Eight (25%) of 32 males over the age of 60 years with nontyphoidal Salmonella bacteraemia had arterial infections. In some patients, the diagnosis of Salmonella arterial infection is likely to be delayed or missed altogether if blood cultures are not obtained. Mortality in patients over the age of 60 years with nontyphoidal Salmonella infections was 28%. Springer-Verlag Berlin Heidelberg, 2000 Ispahani P. Department of Microbiology and Public Health Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK Tel.: +44-115-9521166, Fax: +44-115-9422190, GB aut Slack R. C. B. Department of Microbiology and Public Health Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK Tel.: +44-115-9521166, Fax: +44-115-9422190, GB aut https://doi.org/10.1007/s100960000341 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960000341 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ispahani P. Department of Microbiology and Public Health Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK Tel.: +44-115-9521166, Fax: +44-115-9422190, GB aut NATIONALLICENCE 700 1- Slack R. C. B. Department of Microbiology and Public Health Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK Tel.: +44-115-9521166, Fax: +44-115-9422190, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer