caa a22 4500 475831446 CHVBK 20180406123841.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s100960000355 doi (NATIONALLICENCE)springer-10.1007/s100960000355 Infrequency of Pulmonary Microbial Colonisation Prior to Respiratory Disease in HIV-Infected Individuals [Elektronische Daten] [M. C. I. Lipman, S. Ainscough, P. D. Griffiths, M. A. Johnson, C. C. Kibbler, A. R. S. Deery]  To determine whether organisms are present in the HIV-infected lung prior to clinical respiratory disease, a cross-sectional bronchoscopic comparative analysis of 39 asymptomatic HIV-positive subjects and 31 healthy controls with 2-year prospective bronchoscopic monitoring of the HIV study group was performed. Pathological examination of bronchoalveolar lavage (BAL) fluid using standard microbiological techniques was undertaken. Organisms were recovered from similar numbers of HIV-positive and control subjects (7 of 39 and 3 of 31) and comprised predominantly scanty growths of bacteria. Five subjects developed respiratory disease during follow-up. Repeat BAL was performed in 11 asymptomatic HIV-positive patients; no relationship was found between the organisms isolated at the two procedures. The findings suggest that the asymptomatic HIV-positive lung is not a frequent site of either microbial colonisation or subclinical infection. This has implications for the understanding of the pathogenesis of HIV-related pulmonary disease. Springer-Verlag Berlin Heidelberg, 2000 Lipman M. C. I. Division of Communicable Disease, Royal Free Hospital & School of Medicine, Pond Street, London NW3 2QG, UK e-mail: marclipman@compuserve.com, Tel.: +44-20-78302747, Fax: +44-20-78302747, GB aut Ainscough S. Division of Communicable Disease, Royal Free Hospital & School of Medicine, Pond Street, London NW3 2QG, UK e-mail: marclipman@compuserve.com, Tel.: +44-20-78302747, Fax: +44-20-78302747, GB aut Griffiths P. D. Division of Communicable Disease, Royal Free Hospital & School of Medicine, Pond Street, London NW3 2QG, UK e-mail: marclipman@compuserve.com, Tel.: +44-20-78302747, Fax: +44-20-78302747, GB aut Johnson M. A. Division of Communicable Disease, Royal Free Hospital & School of Medicine, Pond Street, London NW3 2QG, UK e-mail: marclipman@compuserve.com, Tel.: +44-20-78302747, Fax: +44-20-78302747, GB aut Kibbler C. C. Division of Communicable Disease, Royal Free Hospital & School of Medicine, Pond Street, London NW3 2QG, UK e-mail: marclipman@compuserve.com, Tel.: +44-20-78302747, Fax: +44-20-78302747, GB aut Deery A. R. S. Department of Histopathology, Royal Free Hospital & School of Medicine, Pond Street, London NW3 2QG, UK, GB aut https://doi.org/10.1007/s100960000355 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960000355 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lipman M. C. I. Division of Communicable Disease, Royal Free Hospital & School of Medicine, Pond Street, London NW3 2QG, UK e-mail: marclipman@compuserve.com, Tel.: +44-20-78302747, Fax: +44-20-78302747, GB aut NATIONALLICENCE 700 1- Ainscough S. Division of Communicable Disease, Royal Free Hospital & School of Medicine, Pond Street, London NW3 2QG, UK e-mail: marclipman@compuserve.com, Tel.: +44-20-78302747, Fax: +44-20-78302747, GB aut NATIONALLICENCE 700 1- Griffiths P. D. Division of Communicable Disease, Royal Free Hospital & School of Medicine, Pond Street, London NW3 2QG, UK e-mail: marclipman@compuserve.com, Tel.: +44-20-78302747, Fax: +44-20-78302747, GB aut NATIONALLICENCE 700 1- Johnson M. A. Division of Communicable Disease, Royal Free Hospital & School of Medicine, Pond Street, London NW3 2QG, UK e-mail: marclipman@compuserve.com, Tel.: +44-20-78302747, Fax: +44-20-78302747, GB aut NATIONALLICENCE 700 1- Kibbler C. C. Division of Communicable Disease, Royal Free Hospital & School of Medicine, Pond Street, London NW3 2QG, UK e-mail: marclipman@compuserve.com, Tel.: +44-20-78302747, Fax: +44-20-78302747, GB aut NATIONALLICENCE 700 1- Deery A. R. S. Department of Histopathology, Royal Free Hospital & School of Medicine, Pond Street, London NW3 2QG, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer