caa a22 4500 475831497 CHVBK 20180406123841.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s100960000304 doi (NATIONALLICENCE)springer-10.1007/s100960000304 Impact of Moxifloxacin versus Clarithromycin on Normal Oropharyngeal Microflora [Elektronische Daten] [G. Beyer, M. Hiemer-Bau, S. Ziege, C. Edlund, H. Lode, C. E. Nord]  A multiple-dose, randomized, double-blind, controlled, cross-over trial was performed in 12 healthy male subjects in order to investigate the effect of a 7-day treatment with moxifloxacin (400 mg orally, once daily) versus clarithromycin (500 mg orally, twice daily) on the normal oropharyngeal microflora. Moxifloxacin caused significant reductions in levels of alpha-streptococci and Neisseria cocci during the treatment period, while the numbers of gram-negative anaerobic bacteria increased markedly during moxifloxacin administration. Clarithromycin administration caused a suppression of micrococci and corynebacteria, while no significant changes were recorded in the anaerobic microflora. No new colonizing moxifloxacin-resistant strains were isolated during the investigation period. Springer-Verlag Berlin Heidelberg, 2000 Beyer G. Pneumologie und Infektiologie, Hospital Heckeshorn, Freie Universität Berlin, Zum Heckeshorn 33, 14109 Berlin, Germany, DE aut Hiemer-Bau M. Pneumologie und Infektiologie, Hospital Heckeshorn, Freie Universität Berlin, Zum Heckeshorn 33, 14109 Berlin, Germany, DE aut Ziege S. Pneumologie und Infektiologie, Hospital Heckeshorn, Freie Universität Berlin, Zum Heckeshorn 33, 14109 Berlin, Germany, DE aut Edlund C. Department of Microbiology, Pathology and Immunology, F 82, Huddinge University Hospital, 141 86 Stockholm, Sweden e-mail: carl.erik.nord@impi.ki.se, SE aut Lode H. Pneumologie und Infektiologie, Hospital Heckeshorn, Freie Universität Berlin, Zum Heckeshorn 33, 14109 Berlin, Germany, DE aut Nord C. E. Department of Microbiology, Pathology and Immunology, F 82, Huddinge University Hospital, 141 86 Stockholm, Sweden e-mail: carl.erik.nord@impi.ki.se, SE aut https://doi.org/10.1007/s100960000304 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960000304 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beyer G. Pneumologie und Infektiologie, Hospital Heckeshorn, Freie Universität Berlin, Zum Heckeshorn 33, 14109 Berlin, Germany, DE aut NATIONALLICENCE 700 1- Hiemer-Bau M. Pneumologie und Infektiologie, Hospital Heckeshorn, Freie Universität Berlin, Zum Heckeshorn 33, 14109 Berlin, Germany, DE aut NATIONALLICENCE 700 1- Ziege S. Pneumologie und Infektiologie, Hospital Heckeshorn, Freie Universität Berlin, Zum Heckeshorn 33, 14109 Berlin, Germany, DE aut NATIONALLICENCE 700 1- Edlund C. Department of Microbiology, Pathology and Immunology, F 82, Huddinge University Hospital, 141 86 Stockholm, Sweden e-mail: carl.erik.nord@impi.ki.se, SE aut NATIONALLICENCE 700 1- Lode H. Pneumologie und Infektiologie, Hospital Heckeshorn, Freie Universität Berlin, Zum Heckeshorn 33, 14109 Berlin, Germany, DE aut NATIONALLICENCE 700 1- Nord C. E. Department of Microbiology, Pathology and Immunology, F 82, Huddinge University Hospital, 141 86 Stockholm, Sweden e-mail: carl.erik.nord@impi.ki.se, SE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer