caa a22 4500 475831764 CHVBK 20180406123841.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s100960000395 doi (NATIONALLICENCE)springer-10.1007/s100960000395 The Exciting Future of Antifungal Therapy [Elektronische Daten] [M. N. Neely, M. A. Ghannoum]  Invasive fungal infections are becoming more common. Current therapy is generally limited to amphotericin B in its parent and lipid formulations, 5-fluctyosine, fluconazole, and itraconazole. Toxicity, drug-drug interactions, and increasing fungal resistance reduce the usefulness of these drugs, and the need for new therapies is pressing. This article briefly discusses the limitations of antifungal minimum inhibitory testing, and then summarizes new antifungal drugs in development that have been tested in humans. It also addresses novel treatment strategies such as drug combination therapy, pharmacological reformulations to improve the efficacy or reduce the toxicity of current antifungal drugs, immune function augmentation, and vaccine development. All of these strategies, although in their infancy, will enhance the clinician's ability to care for patients with invasive fungal infections. Springer-Verlag Berlin Heidelberg, 2000 Neely M. N. Department of Pediatrics, Division of Infectious Diseases and Division of Clinical Pharmacology, Rainbow Babies and Children's Hospital, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA e-mail: mnn2@po.cwru.edu, US aut Ghannoum M. A. Department of Dermatology, Center for Medical Mycology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA e-mail: mag3@po.cwru.edu, US aut https://doi.org/10.1007/s100960000395 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960000395 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Neely M. N. Department of Pediatrics, Division of Infectious Diseases and Division of Clinical Pharmacology, Rainbow Babies and Children's Hospital, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA e-mail: mnn2@po.cwru.edu, US aut NATIONALLICENCE 700 1- Ghannoum M. A. Department of Dermatology, Center for Medical Mycology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA e-mail: mag3@po.cwru.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer