caa a22 4500 475831845 CHVBK 20180406123842.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s100960050454 doi (NATIONALLICENCE)springer-10.1007/s100960050454 Serological Methods for Diagnosis of Helicobacter pylori Infection and Monitoring of Eradication Therapy [Elektronische Daten] [P. Herbrink, L.J. van Doorn]  Several methods can be used to diagnose Helicobacter pylori infection. Invasive methods include detection of the bacterium in gastric biopsy specimens by culture, immunohistochemistry, rapid urease tests, or the polymerase chain reaction. Noninvasive or less invasive detection methods include the urea breath test and serological methods. The urea breath test is based on the detection of 13CO2 or 14CO2 in breath, produced by bacterial urease in the stomach after labelled urea is swallowed. Serological methods are based on the detection of Helicobacter pylori-specific antibodies in serum, saliva, or urine. In this review, the performance and diagnostic value of several serological methods, such as enzyme immunoassay, rapid office-based assays, and Western blot, will be discussed in relation to biopsy-based methods and the urea breath test. In addition, the value of serological assays for monitoring eradication of Helicobacter pylori infection following treatment will be discussed. The diagnostic performance of properly evaluated serological assays is comparable to that of biopsy-based methods and the urea breath test. To monitor eradication of Helicobacter pylori infection following therapy, quantitative enzyme immunoassays can be used, especially in patients with high pretreatment antibody titres. Springer-Verlag Berlin Heidelberg, 2000 Herbrink P. Diagnostic Centre SSDZ, Medical Laboratories, Reinier de Graafweg 7, 2625 AD Delft, The Netherlands e-mail: herbrink@rdgg.nl, NL aut van Doorn L.J. Delft Diagnostic Laboratory, Reinier de Graafweg 7, 2625 AD Delft, The Netherlands, NL aut https://doi.org/10.1007/s100960050454 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050454 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Herbrink P. Diagnostic Centre SSDZ, Medical Laboratories, Reinier de Graafweg 7, 2625 AD Delft, The Netherlands e-mail: herbrink@rdgg.nl, NL aut NATIONALLICENCE 700 1- van Doorn L.J. Delft Diagnostic Laboratory, Reinier de Graafweg 7, 2625 AD Delft, The Netherlands, NL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer