caa a22 4500 475831918 CHVBK 20180406123842.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s100960050456 doi (NATIONALLICENCE)springer-10.1007/s100960050456 Molecular Evidence of Nosocomial Transmission of Hepatitis C Virus in a Haemodialysis Unit [Elektronische Daten] [Y. H. Abacioglu, F. Bacaksiz, I. H. Bahar, P. Simmonds]  The molecular epidemiology of type 2a hepatitis C virus (HCV) infections in patients undergoing haemodialysis in the same unit in a Turkish hospital was investigated. Of nine HCV-infected patients four were infected with type 2a, four with type 1b and one with type 1a viruses. Since type 2 HCV infections in the Turkish population are rare, the possibility of nosocomial infection was investigated by means of phylogenetic analysis of viral sequences amplified by the polymerase chain reaction in the NS5b region. One of the samples failed to show amplification and therefore could not be sequenced. The sequences of the remaining three virus samples were grouped closely in a cluster within the type 2a group. The results thus showed that three patients were infected with the same HCV type 2a strain. Seroconversion and clinical data suggested that these patients may have been infected on different occasions, there being possibly more than one mode of transmission. Breaches in infection control procedures and lack of environmental decontamination between two haemodialysis sessions were probably the causes of HCV infections in these patients. Springer-Verlag Berlin Heidelberg, 2000 Abacioglu Y. H. Department of Microbiology, Dokuz Eylül University School of Medicine, Inciralti 35340-Izmir, Turkey e-mail: abacih@cs.med.deu.edu.tr, TR aut Bacaksiz F. Department of Microbiology, Dokuz Eylül University School of Medicine, Inciralti 35340-Izmir, Turkey e-mail: abacih@cs.med.deu.edu.tr, TR aut Bahar I. H. Department of Microbiology, Dokuz Eylül University School of Medicine, Inciralti 35340-Izmir, Turkey e-mail: abacih@cs.med.deu.edu.tr, TR aut Simmonds P. Department of Medical Microbiology, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK, GB aut https://doi.org/10.1007/s100960050456 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050456 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abacioglu Y. H. Department of Microbiology, Dokuz Eylül University School of Medicine, Inciralti 35340-Izmir, Turkey e-mail: abacih@cs.med.deu.edu.tr, TR aut NATIONALLICENCE 700 1- Bacaksiz F. Department of Microbiology, Dokuz Eylül University School of Medicine, Inciralti 35340-Izmir, Turkey e-mail: abacih@cs.med.deu.edu.tr, TR aut NATIONALLICENCE 700 1- Bahar I. H. Department of Microbiology, Dokuz Eylül University School of Medicine, Inciralti 35340-Izmir, Turkey e-mail: abacih@cs.med.deu.edu.tr, TR aut NATIONALLICENCE 700 1- Simmonds P. Department of Medical Microbiology, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer