caa a22 4500 475831969 CHVBK 20180406123842.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s100960050460 doi (NATIONALLICENCE)springer-10.1007/s100960050460 Infection Caused by Nocardia farcinica [Elektronische Daten] Case Report and Review [O. H. Torres, P. Domingo, R. Pericas, P. Boiron, J. A. Montiel, G. Vázquez]  Nocardia farcinica is a rare Nocardia species causing localised and disseminated infections. A case of Nocardia farcinica infection is presented, and 52 cases previously reported in the literature are reviewed. The hosts usually had predisposing conditions (85%), and acquired the infection through the respiratory tract or skin; the infection then often spread to the brain, kidney, joints, bones and eyes. Pulmonary or pleural infections (43%), brain abscesses (30%) and wound infections (15%) which failed to respond to conventional antimicrobial therapy were the more frequent forms of infection. Nocardia farcinica was frequently isolated from pus (100% of samples), bronchial secretions (41%) and biopsy specimens (63%), but isolation from blood and urine, as in the case presented here, is rare. Antibiotic therapy was adequate in 61% of the patients in whom it was specified, the agents most frequently given being trimethoprim-sulfamethoxazole (54%), amikacin combined with imipenem (7%) and amoxicillin-clavulanate (7%). The high mortality (31%) can be attributed to the severe underlying diseases present, difficulties encountered in identifying the pathogen, inappropriate therapy and late initiation of therapy. Although an infrequent pathogen, Nocardia farcinica should be kept in mind as a cause of infection especially in immunosuppressed patients with indolent infections not responding to third-generation cephalosporins. Springer-Verlag Berlin Heidelberg, 2000 Torres O. H. Department of Internal Medicine (Infectious Diseases Unit), Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avinguda, Sant Antoni Ma Claret 167, 08025 Barcelona, Spain e-mail: pere.domingo@cc.uab.es, ES aut Domingo P. Department of Internal Medicine (Infectious Diseases Unit), Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avinguda, Sant Antoni Ma Claret 167, 08025 Barcelona, Spain e-mail: pere.domingo@cc.uab.es, ES aut Pericas R. Department of Microbiology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avinguda, Sant Antoni Ma Claret 167, 08025 Barcelona, Spain, ES aut Boiron P. Laboratoire de Mycologie Fondamentale, et Appliquée aux Biotechnologies Industrielles, Faculté de Pharmacie, Institut des Sciences Pharmaceutiques et Biologiques, 8, Avenue Rockefeller, 69373 Lyon Cedex 08, France, FR aut Montiel J. A. Department of Internal Medicine (Infectious Diseases Unit), Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avinguda, Sant Antoni Ma Claret 167, 08025 Barcelona, Spain e-mail: pere.domingo@cc.uab.es, ES aut Vázquez G. Department of Internal Medicine (Infectious Diseases Unit), Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avinguda, Sant Antoni Ma Claret 167, 08025 Barcelona, Spain e-mail: pere.domingo@cc.uab.es, ES aut https://doi.org/10.1007/s100960050460 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050460 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Torres O. H. Department of Internal Medicine (Infectious Diseases Unit), Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avinguda, Sant Antoni Ma Claret 167, 08025 Barcelona, Spain e-mail: pere.domingo@cc.uab.es, ES aut NATIONALLICENCE 700 1- Domingo P. Department of Internal Medicine (Infectious Diseases Unit), Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avinguda, Sant Antoni Ma Claret 167, 08025 Barcelona, Spain e-mail: pere.domingo@cc.uab.es, ES aut NATIONALLICENCE 700 1- Pericas R. Department of Microbiology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avinguda, Sant Antoni Ma Claret 167, 08025 Barcelona, Spain, ES aut NATIONALLICENCE 700 1- Boiron P. Laboratoire de Mycologie Fondamentale, et Appliquée aux Biotechnologies Industrielles, Faculté de Pharmacie, Institut des Sciences Pharmaceutiques et Biologiques, 8, Avenue Rockefeller, 69373 Lyon Cedex 08, France, FR aut NATIONALLICENCE 700 1- Montiel J. A. Department of Internal Medicine (Infectious Diseases Unit), Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avinguda, Sant Antoni Ma Claret 167, 08025 Barcelona, Spain e-mail: pere.domingo@cc.uab.es, ES aut NATIONALLICENCE 700 1- Vázquez G. Department of Internal Medicine (Infectious Diseases Unit), Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avinguda, Sant Antoni Ma Claret 167, 08025 Barcelona, Spain e-mail: pere.domingo@cc.uab.es, ES aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer