caa a22 4500 475831993 CHVBK 20180406123842.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s100960050465 doi (NATIONALLICENCE)springer-10.1007/s100960050465 Comparative Activity of Moxifloxacin in Vitro Against Obligately Anaerobic Bacteria [Elektronische Daten] [G. Ackermann, R. Schaumann, B. Pless, M. C. Claros, E. J. C. Goldstein, A. C. Rodloff]  The antimicrobial activity of moxifloxacin and seven other antibiotics (four of them quinolones) against 292 strains of obligately anaerobic bacteria was assessed employing a broth microdilution technique performed in Wilkens-Chalgren broth. MIC50/MIC90 values (mg/l) for moxifloxacin were as follows: Bacteroides fragilis (n=62) 0.25/2, Bacteroides ovatus (n=70) 1/4, Bacteroides vulgatus (n=29) 0.25/1, Bacteroides thetaiotaomicron (n=17) 2/2, Bacteroides caccae (n=11) 1/2, Prevotella spp. (n=11) 0.25/2, Fusobacterium spp. (n=17) 1/4, Bilophila wadsworthia (n=29) 0.5/1, and Clostridium spp. (n=29) 0.125/0.5, respectively. MIC50 values (mg/l) for Bacteroides distasonis (n=8) and Peptostreptococcus spp. (n=9) were 0.25. The results indicated that moxifloxacin was almost as active as trovafloxacin, as active as gatifloxacin, and more active than levofloxacin and ciprofloxacin against the anaerobes tested. Springer-Verlag Berlin Heidelberg, 2000 Ackermann G. Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstr. 24, 04109 Leipzig, Germany e-mail: ackermg@medizin.uni-leipzig.de, DE aut Schaumann R. Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstr. 24, 04109 Leipzig, Germany e-mail: ackermg@medizin.uni-leipzig.de, DE aut Pless B. Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstr. 24, 04109 Leipzig, Germany e-mail: ackermg@medizin.uni-leipzig.de, DE aut Claros M. C. Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstr. 24, 04109 Leipzig, Germany e-mail: ackermg@medizin.uni-leipzig.de, DE aut Goldstein E. J. C. R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, USA, US aut Rodloff A. C. Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstr. 24, 04109 Leipzig, Germany e-mail: ackermg@medizin.uni-leipzig.de, DE aut https://doi.org/10.1007/s100960050465 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050465 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ackermann G. Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstr. 24, 04109 Leipzig, Germany e-mail: ackermg@medizin.uni-leipzig.de, DE aut NATIONALLICENCE 700 1- Schaumann R. Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstr. 24, 04109 Leipzig, Germany e-mail: ackermg@medizin.uni-leipzig.de, DE aut NATIONALLICENCE 700 1- Pless B. Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstr. 24, 04109 Leipzig, Germany e-mail: ackermg@medizin.uni-leipzig.de, DE aut NATIONALLICENCE 700 1- Claros M. C. Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstr. 24, 04109 Leipzig, Germany e-mail: ackermg@medizin.uni-leipzig.de, DE aut NATIONALLICENCE 700 1- Goldstein E. J. C. R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, USA, US aut NATIONALLICENCE 700 1- Rodloff A. C. Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstr. 24, 04109 Leipzig, Germany e-mail: ackermg@medizin.uni-leipzig.de, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer