caa a22 4500 475832124 CHVBK 20180406123843.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s100960000371 doi (NATIONALLICENCE)springer-10.1007/s100960000371 Evaluation of a Helicobacter pylori Stool Antigen Test for the Diagnosis and Follow-Up of Infections in Children [Elektronische Daten] [M. O. Husson, C. Rolland, F. Gottrand, D. Guimber, N. Kalach, C. Spyckerelle, C. Lenaerts, P. S. Ganga-Zandzou]  The aim of this study was to evaluate the performance of a newly developed enzyme immunoassay kit (HpSA) for detecting Helicobacter pylori antigens in the stool of children. This study was comprised of 58 children referred to various endoscopy units for evaluation of gastrointestinal symptoms and upper gastroduodenal endoscopy and 11 children for post-therapy follow-up. In the first group, 23 children were diagnosed as positive for Helicobacter pylori using bacteriological and/or histological methods. Stool antigens were detected in 20 of these positive patients, for a sensitivity of 86.9% and a negative predictive value of 91.9%. Since only one false-positive reaction was observed with the HpSA kit, the specificity was 97.1% and the positive predictive value 95.2%. Results obtained for post-therapy follow-up were also promising. The HpSA assays were negative for the eight children whose infections were eradicated after therapy, and a positive result was obtained for two of three patients who had a persistent infection. Springer-Verlag Berlin Heidelberg, 2000 Husson M. O. Laboratoire de Bactériologie-Hygiène, Hôpital Calmette, Bd. Pr. J. Leclercq, 59037 Lille, France, FR aut Rolland C. Laboratoire de Bactériologie-Hygiène, Hôpital Calmette, Bd. Pr. J. Leclercq, 59037 Lille, France, FR aut Gottrand F. Service de Gastroentérologie, Hépatologie et Nutrition, Hôpital Jeanne de Flandre, 2 Av. O. Lambret, 59037 Lille Cedex, France, FR aut Guimber D. Service de Gastroentérologie, Hépatologie et Nutrition, Hôpital Jeanne de Flandre, 2 Av. O. Lambret, 59037 Lille Cedex, France, FR aut Kalach N. Service de Pédiatrie, Centre Hospitalier Laennec, Bd. Laennec, 60100 Creil, France, FR aut Spyckerelle C. Hôpital Saint Antoine, Bd. V. Hugo, 59000 Lille, France, FR aut Lenaerts C. Service de Pédiatrie, Centre Hospitalier, 80000 Amiens, France, FR aut Ganga-Zandzou P. S. Service de Pédiatrie, Centre Hospitalier de Roubaix, 591000 Roubaix, France, FR aut https://doi.org/10.1007/s100960000371 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960000371 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Husson M. O. Laboratoire de Bactériologie-Hygiène, Hôpital Calmette, Bd. Pr. J. Leclercq, 59037 Lille, France, FR aut NATIONALLICENCE 700 1- Rolland C. Laboratoire de Bactériologie-Hygiène, Hôpital Calmette, Bd. Pr. J. Leclercq, 59037 Lille, France, FR aut NATIONALLICENCE 700 1- Gottrand F. Service de Gastroentérologie, Hépatologie et Nutrition, Hôpital Jeanne de Flandre, 2 Av. O. Lambret, 59037 Lille Cedex, France, FR aut NATIONALLICENCE 700 1- Guimber D. Service de Gastroentérologie, Hépatologie et Nutrition, Hôpital Jeanne de Flandre, 2 Av. O. Lambret, 59037 Lille Cedex, France, FR aut NATIONALLICENCE 700 1- Kalach N. Service de Pédiatrie, Centre Hospitalier Laennec, Bd. Laennec, 60100 Creil, France, FR aut NATIONALLICENCE 700 1- Spyckerelle C. Hôpital Saint Antoine, Bd. V. Hugo, 59000 Lille, France, FR aut NATIONALLICENCE 700 1- Lenaerts C. Service de Pédiatrie, Centre Hospitalier, 80000 Amiens, France, FR aut NATIONALLICENCE 700 1- Ganga-Zandzou P. S. Service de Pédiatrie, Centre Hospitalier de Roubaix, 591000 Roubaix, France, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer