caa a22 4500 475832175 CHVBK 20180406123843.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s100960050477 doi (NATIONALLICENCE)springer-10.1007/s100960050477 Carriage of Antibiotic-Resistant Streptococcus pneumoniae in Greek Infants and Toddlers [Elektronische Daten] [G. A. Syrogiannopoulos, I. N. Grivea, G. D. Katopodis, P. Geslin, M. R. Jacobs, N. G. Beratis] The prevalence, resistance patterns and serotypes of antibiotic-resistant Streptococcus pneumoniae strains recovered from Greek carriers under 24 months of age were studied. From February 1997 to April 1998, nasopharyngeal cultures were performed in 1269 children (ages 2-23 months, median 11 months) living in various areas of central and southern Greece. Resistance (including both intermediate and resistant isolates) to one or more antimicrobial agents was found in 132 of the 421 (31%) Streptococcus pneumoniae isolates, as follows: penicillin, 9% intermediate, 7.6% resistant; cefotaxime, 5.2% intermediate, 0.5% resistant; erythromycin, 0.7% intermediate, 18.1% resistant; clindamycin, 0.2% intermediate, 12.4% resistant; tetracycline, 0.7% intermediate, 16.4% resistant; chloramphenicol, 12.4% resistant; and trimethoprim-sulfamethoxazole, 3.8% intermediate, 14.3% resistant. The MICs of penicillin for 66% of the penicillin-nonsusceptible pneumococci were 1-4 μg/ml. Multidrug resistance was found in 64% of penicillin-nonsusceptible and 37% of penicillin-susceptible strains. Sixty-two percent of the penicillin-susceptible, multidrug-resistant strains belonged to serotype 6B and were resistant to all five non-β-lactam agents tested. This notable serotype 6B resistance pattern was described for the first time in a previous study performed from December 1995 to February 1996 in the city of Patras, southwestern Greece. Seventy-two percent of antibiotic-resistant isolates belonged to serotypes 6B, 9V, 14, 18C, 19F and 23F. These results document the spread of resistant pneumococcal strains in central and southern Greece, many of which are multidrug resistant. Springer-Verlag Berlin Heidelberg, 2000 Syrogiannopoulos G. A. Department of Pediatrics, University of Patras, School of Medicine, 265 00 Rion, Patras, Greece e-mail: syrogian@med.upatras.gr, GR aut Grivea I. N. Department of Pediatrics, University of Patras, School of Medicine, 265 00 Rion, Patras, Greece e-mail: syrogian@med.upatras.gr, GR aut Katopodis G. D. Department of Pediatrics, University of Patras, School of Medicine, 265 00 Rion, Patras, Greece e-mail: syrogian@med.upatras.gr, GR aut Geslin P. Centre National de Référence du Pneumocoque, 40 Avenue de Verdun, 94010 Créteil Cedex, France, FR aut Jacobs M. R. Department of Pathology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Cleveland, Ohio 44106, USA, US aut Beratis N. G. Department of Pediatrics, University of Patras, School of Medicine, 265 00 Rion, Patras, Greece e-mail: syrogian@med.upatras.gr, GR aut https://doi.org/10.1007/s100960050477 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050477 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Syrogiannopoulos G. A. Department of Pediatrics, University of Patras, School of Medicine, 265 00 Rion, Patras, Greece e-mail: syrogian@med.upatras.gr, GR aut NATIONALLICENCE 700 1- Grivea I. N. Department of Pediatrics, University of Patras, School of Medicine, 265 00 Rion, Patras, Greece e-mail: syrogian@med.upatras.gr, GR aut NATIONALLICENCE 700 1- Katopodis G. D. Department of Pediatrics, University of Patras, School of Medicine, 265 00 Rion, Patras, Greece e-mail: syrogian@med.upatras.gr, GR aut NATIONALLICENCE 700 1- Geslin P. Centre National de Référence du Pneumocoque, 40 Avenue de Verdun, 94010 Créteil Cedex, France, FR aut NATIONALLICENCE 700 1- Jacobs M. R. Department of Pathology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Cleveland, Ohio 44106, USA, US aut NATIONALLICENCE 700 1- Beratis N. G. Department of Pediatrics, University of Patras, School of Medicine, 265 00 Rion, Patras, Greece e-mail: syrogian@med.upatras.gr, GR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer