caa a22 4500 475832191 CHVBK 20180406123843.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s100960050484 doi (NATIONALLICENCE)springer-10.1007/s100960050484 In Vitro Susceptibility of Environmental Cryptococcus neoformans Variety neoformans Isolates from Turkey to Six Antifungal Agents, Including SCH56592 and Voriconazole [Elektronische Daten] [S. T. Yildiran, M. A. Saracli, A. W. Fothergill, M. G. Rinaldi]  The in vitro antifungal susceptibility of 27 environmental (pigeon droppings) isolates of Cryptococcus neoformans var. neoformans, isolated from throughout Turkey, to six antifungal agents (amphotericin B, flucytosine, fluconazole, voriconazole, itraconazole, and SCH56592) was studied. Voriconazole, itraconazole, and SCH56592 all showed comparable activity and were more active than the remaining three antifungal agents tested. Overall, SCH56592 was the most active agent (MIC90, 0.015 μg/ml, at both 48 and 72 h), followed by itraconazole (MIC90, 0.03 μg/ml, at both 48 and 72 h) and voriconazole (MIC90, 0.25 μg/ml, at both 48 and 72 h), respectively. Antifungal susceptibility data for environmental isolates may reflect patterns for the clinical isolates recovered from patients from the same geographic area. Springer-Verlag Berlin Heidelberg, 2000 Yildiran S. T. Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284-7750, USA, US aut Saracli M. A. Division of Medical Mycology, Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy and School of Medicine, Ankara 06018, Turkey, TR aut Fothergill A. W. Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284-7750, USA, US aut Rinaldi M. G. Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284-7750, USA, US aut https://doi.org/10.1007/s100960050484 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050484 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yildiran S. T. Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284-7750, USA, US aut NATIONALLICENCE 700 1- Saracli M. A. Division of Medical Mycology, Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy and School of Medicine, Ankara 06018, Turkey, TR aut NATIONALLICENCE 700 1- Fothergill A. W. Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284-7750, USA, US aut NATIONALLICENCE 700 1- Rinaldi M. G. Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284-7750, USA, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer