caa a22 4500 475832272 CHVBK 20180406123843.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s100960050483 doi (NATIONALLICENCE)springer-10.1007/s100960050483 Role of Bacterial Virulence Factors and Host Factors in the Outcome of Escherichia coli Bacteraemia [Elektronische Daten] [T. A. M. Hekker, A. B. J. Groeneveld, A. M. Simoons-Smit, P. de Man, H. Connell, D. M. MacLaren]  In a study of the role of virulence factors in the outcome of Escherichia coli bacteraemia, blood isolates from 30 hospitalised patients were characterised with regard to O and K antigens, P and type 1 fimbriae, haemolysin production, cytonecrotising factor 1 production, serum resistance, ability to activate neutrophils and resistance to killing. Patients were analysed to identify host factors contributing to morbidity and mortality. In univariate analyses the presence of a K antigen, type 1 fimbriae, absence of haemolysin production, serum resistance and resistance to killing were associated with morbidity and mortality. In multivariate analyses only the absence of haemolysin production was associated with morbidity and mortality, after taking host factors into account. These preliminary findings suggest that host factors override bacterial virulence factors in determining the course of Escherichia coli bacteraemia. The negative association between haemolysin production and clinical deterioration during Escherichia coli bacteraemia might indicate predominance of less virulent strains in patients with other risk factors for morbidity and mortality or inactivation of neutrophil products needed for host defence. Springer-Verlag Berlin Heidelberg, 2000 Hekker T. A. M. Department of Medical Microbiology and Infection Control, University Hospital "Vrije Universiteit", P.O. Box 7057, 1007 MB Amsterdam, The Netherlands e-mail: tam.hekker@a2vu.nl, NL aut Groeneveld A. B. J. Department of Internal Medicine, University Hospital "Vrije Universiteit", Amsterdam, The Netherlands, NL aut Simoons-Smit A. M. Department of Medical Microbiology and Infection Control, University Hospital "Vrije Universiteit", P.O. Box 7057, 1007 MB Amsterdam, The Netherlands e-mail: tam.hekker@a2vu.nl, NL aut de Man P. Department of Medical Microbiology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands, NL aut Connell H. Department of Medical Microbiology, Division of Clinical Immunology, Lund University, Lund, Sweden, SE aut MacLaren D. M. Department of Medical Microbiology and Infection Control, University Hospital "Vrije Universiteit", P.O. Box 7057, 1007 MB Amsterdam, The Netherlands e-mail: tam.hekker@a2vu.nl, NL aut https://doi.org/10.1007/s100960050483 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050483 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hekker T. A. M. Department of Medical Microbiology and Infection Control, University Hospital "Vrije Universiteit", P.O. Box 7057, 1007 MB Amsterdam, The Netherlands e-mail: tam.hekker@a2vu.nl, NL aut NATIONALLICENCE 700 1- Groeneveld A. B. J. Department of Internal Medicine, University Hospital "Vrije Universiteit", Amsterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- Simoons-Smit A. M. Department of Medical Microbiology and Infection Control, University Hospital "Vrije Universiteit", P.O. Box 7057, 1007 MB Amsterdam, The Netherlands e-mail: tam.hekker@a2vu.nl, NL aut NATIONALLICENCE 700 1- de Man P. Department of Medical Microbiology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- Connell H. Department of Medical Microbiology, Division of Clinical Immunology, Lund University, Lund, Sweden, SE aut NATIONALLICENCE 700 1- MacLaren D. M. Department of Medical Microbiology and Infection Control, University Hospital "Vrije Universiteit", P.O. Box 7057, 1007 MB Amsterdam, The Netherlands e-mail: tam.hekker@a2vu.nl, NL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer