caa a22 4500 475832337 CHVBK 20180406123843.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s100960050474 doi (NATIONALLICENCE)springer-10.1007/s100960050474 Transient Transmission of Hepatitis C Virus from Mothers to Newborns [Elektronische Daten] [M. Ketzinel-Gilad, S. L. Colodner, R. Hadary, E. Granot, D. Shouval, E. Galun]  A study was performed in Israel to determine the rate of mother-to-infant HCV transmission in newborns at risk. A group of 22 HCV-infected mothers and their 23 newborns were followed up from early after birth by testing their serum for the presence of HCV antibodies and HCV-RNA. Antibody against HCV was detected in the blood of all newborns immediately after birth, but dropped to low or undetectable levels by 7 months of age. HCV-RNA was detected 2 days after birth in the blood of five infants (22%) but fell to undetectable levels by 6 months. HCV-HVR1 sequence analysis performed in one mother-infant pair on the second day after birth revealed two nucleotide changes. Two months later the same sequence was detected again in the HVR1, suggesting a very low replication rate. Thus, the study showed that vertically transmitted HCV was eliminated in all newborn infants by 6 months after delivery, with concomitant disappearance of HCV antibodies. The mechanism of HCV elimination in newborns at risk remains to be elucidated. Springer-Verlag Berlin Heidelberg, 2000 Ketzinel-Gilad M. Liver Unit, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel, IL aut Colodner S. L. Liver Unit, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel, IL aut Hadary R. Liver Unit, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel, IL aut Granot E. Department of Pediatrics, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel, IL aut Shouval D. Liver Unit, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel, IL aut Galun E. Goldyne Savad Gene Therapy Institute, Hadassah University Hospital, PO Box 12000, Ein Kerem, 91120 Jerusalem, Israel e-mail: galun@md2.huji.ac.il, IL aut https://doi.org/10.1007/s100960050474 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050474 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ketzinel-Gilad M. Liver Unit, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel, IL aut NATIONALLICENCE 700 1- Colodner S. L. Liver Unit, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel, IL aut NATIONALLICENCE 700 1- Hadary R. Liver Unit, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel, IL aut NATIONALLICENCE 700 1- Granot E. Department of Pediatrics, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel, IL aut NATIONALLICENCE 700 1- Shouval D. Liver Unit, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel, IL aut NATIONALLICENCE 700 1- Galun E. Goldyne Savad Gene Therapy Institute, Hadassah University Hospital, PO Box 12000, Ein Kerem, 91120 Jerusalem, Israel e-mail: galun@md2.huji.ac.il, IL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer