caa a22 4500 475832361 CHVBK 20180406123843.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s100960000330 doi (NATIONALLICENCE)springer-10.1007/s100960000330 In Vitro Zones of Inhibition of Coated Vascular Catheters Predict Efficacy in Preventing Catheter Infection with Staphylococcus aureus In Vivo [Elektronische Daten] [S. Bassetti, J. Hu, R.B. D'Agostino Jr., R. J. Sherertz]  This report summarizes data from 35 rabbit model experiments investigating the relationship between in vitro anti-infective catheter coating zones of inhibition and in vivo efficacy. The rabbit model studies involving 15 anti-infective coatings demonstrate an inverse correlation between the sizes of zones of inhibition of Staphylococcus aureus and both the quantity of Staphylococcus aureus removed from the catheter and the risk of a purulent infection. The review of seven previously published clinical trials reveals that the use of anti-infective coated catheters, efficacious in the rabbit model, was associated with a higher success rate than the use of uncoated catheters in preventing both Staphylococcus aureus catheter colonization (odds ratio: 1.28; 95% confidence interval: 0.84-1.93) and Staphylococcus aureus catheter-related bloodstream infection (odds ratio: 3.07; 95% confidence interval: 0.98-9.60) in humans. These findings strongly suggest a correlation between zones of inhibition and in vivo efficacy. In vitro zones of inhibition may serve as a useful screening test for evaluating new anti-infective coatings. Springer-Verlag Berlin Heidelberg, 2000 Bassetti S. Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042, USA e-mail: sherertz@wfubmc.edu, US aut Hu J. Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042, USA e-mail: sherertz@wfubmc.edu, US aut D'Agostino Jr. R.B. Section on Biostatistics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042, USA, US aut Sherertz R. J. Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042, USA e-mail: sherertz@wfubmc.edu, US aut https://doi.org/10.1007/s100960000330 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960000330 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bassetti S. Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042, USA e-mail: sherertz@wfubmc.edu, US aut NATIONALLICENCE 700 1- Hu J. Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042, USA e-mail: sherertz@wfubmc.edu, US aut NATIONALLICENCE 700 1- D'Agostino Jr R.B. Section on Biostatistics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042, USA, US aut NATIONALLICENCE 700 1- Sherertz R. J. Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042, USA e-mail: sherertz@wfubmc.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer