caa a22 4500 475832388 CHVBK 20180406123843.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s100960000335 doi (NATIONALLICENCE)springer-10.1007/s100960000335 Clinical Manifestations and Molecular Epidemiology of Late Recurrent Candidemia, and Implications for Management [Elektronische Daten] [C. J. Clancy, F. Barchiesi, L. Falconi DiFrancesco, A. J. Morris, D. R. Snydman, V. L. Yu, G. Scalise, M. H. Nguyen]  The aim of this study was to define the epidemiology and clinical manifestations of late recurrent candidemia. For this purpose, late recurrent candidemia was defined as an episode of candidemia occurring at least 1 month after the apparent complete resolution of an infectious episode caused by the same Candida sp. A total of five patients with recurrent candidemia were investigated. For all patients, isolates from the initial and recurrent episodes of candidemia were available for in vitro susceptibility testing and genetic characterization by DNA-based techniques. The results revealed the following salient features: prolonged duration between the initial and recurrent episodes (range, 1-8 months); recurrence of candidemia despite antifungal therapy; importance of retained intravascular catheters, neutropenia, and corticosteroids as factors predisposing to recurrence; high morbidity and mortality; no emergence of antifungal drug resistance between the initial and recurrent episodes; and relapse of infection due to the original infecting strain, rather than reinfection with a new strain. These findings raise several issues about the management and follow-up of patients with candidemia, which require assessment in future studies. Springer-Verlag Berlin Heidelberg, 2000 Clancy C. J. University of Florida College of Medicine and Veterans Administration Medical Center, Gainesville, FL 32610, USA e-mail: clancyn@medicine.ufl.edu, US aut Barchiesi F. Istituto de Malattie Infettive & Medicina Pubblica, Universita degli Studi di Ancona, Ancona, Italy, IT aut Falconi DiFrancesco L. Istituto de Malattie Infettive & Medicina Pubblica, Universita degli Studi di Ancona, Ancona, Italy, IT aut Morris A. J. Duke University Medical Center, Durham, NC, USA, US aut Snydman D. R. New England Medical Center, Boston, MA, USA, GB aut Yu V. L. University of Pittsburgh and VA Medical Center, Pittsburgh, PA, USA, US aut Scalise G. Istituto de Malattie Infettive & Medicina Pubblica, Universita degli Studi di Ancona, Ancona, Italy, IT aut Nguyen M. H. University of Florida College of Medicine and Veterans Administration Medical Center, Gainesville, FL 32610, USA e-mail: clancyn@medicine.ufl.edu, US aut https://doi.org/10.1007/s100960000335 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960000335 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Clancy C. J. University of Florida College of Medicine and Veterans Administration Medical Center, Gainesville, FL 32610, USA e-mail: clancyn@medicine.ufl.edu, US aut NATIONALLICENCE 700 1- Barchiesi F. Istituto de Malattie Infettive & Medicina Pubblica, Universita degli Studi di Ancona, Ancona, Italy, IT aut NATIONALLICENCE 700 1- Falconi DiFrancesco L. Istituto de Malattie Infettive & Medicina Pubblica, Universita degli Studi di Ancona, Ancona, Italy, IT aut NATIONALLICENCE 700 1- Morris A. J. Duke University Medical Center, Durham, NC, USA, US aut NATIONALLICENCE 700 1- Snydman D. R. New England Medical Center, Boston, MA, USA, GB aut NATIONALLICENCE 700 1- Yu V. L. University of Pittsburgh and VA Medical Center, Pittsburgh, PA, USA, US aut NATIONALLICENCE 700 1- Scalise G. Istituto de Malattie Infettive & Medicina Pubblica, Universita degli Studi di Ancona, Ancona, Italy, IT aut NATIONALLICENCE 700 1- Nguyen M. H. University of Florida College of Medicine and Veterans Administration Medical Center, Gainesville, FL 32610, USA e-mail: clancyn@medicine.ufl.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer