caa a22 4500 475832485 CHVBK 20180406123844.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s100960000325 doi (NATIONALLICENCE)springer-10.1007/s100960000325 Nosocomial Candidemia in Non-Neutropenic Patients at an Italian Tertiary Care Hospital [Elektronische Daten] [R. Luzzati, G. Amalfitano, L. Lazzarini, F. Soldani, S. Bellino, M. Solbiati, M. C. Danzi, S. Vento, G. Todeschini, C. Vivenza, E. Concia]  In a retrospective study conducted in an Italian tertiary care hospital, the incidence of nosocomial candidemia was evaluated together with causative pathogens, treatment, and risk factors for death. Over a 6-year period (1992-1997), a total of 189 episodes of candidemia occurred in 189 patients (mean age 58±19 years), accounting for an average incidence of 1.14 episodes per 10,000 patient-days per year. The most common reasons for hospitalization were solid neoplasia (21%), trauma (17%), abdominal diseases requiring surgery (13%), and cardiovascular diseases (13%). No patient was neutropenic within 3 weeks prior to the onset of candidemia. One hundred thirty patients were hospitalized in intensive care units, 47 patients in surgical wards, and 12 patients in medical wards. Candida albicans was the most frequently isolated pathogen, accounting for 54% of fungal isolates, followed by Candida parapsilosis (23%), Candida glabrata (7%), Candida tropicalis (5%), Candida pelliculosa (4%), Candida lusitaniae (1%), Candida humicula (1%), and other non-albicans Candida spp. (5%). Seventy-six (41%) patients received adequate antifungal therapy. Seventy-one (58%) of the 123 evaluable patients with central venous catheters underwent line removal; 51 of them had catheter-related candidemia. The 30-day crude mortality rate was 45%. Older age, hospitalization in an intensive care unit, a longer duration of candidemia, retention of central lines, and inadequate antifungal therapy were significantly associated with poor outcome. In the present study, nosocomial candidemia was a frequent and relatively underestimated illness. Adequate antifungal therapy and central line removal independently reduced the high mortality of the disease. Springer-Verlag Berlin Heidelberg, 2000 Luzzati R. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut Amalfitano G. Laboratory for Microbiology and Virology, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy, IT aut Lazzarini L. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut Soldani F. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut Bellino S. Informa, Via dei Magazzini Generali 31, 00154 Rome, Italy, IT aut Solbiati M. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut Danzi M. C. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut Vento S. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut Todeschini G. Cancer Clinical Centre, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy, IT aut Vivenza C. Intensive Care Services, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy, IT aut Concia E. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut https://doi.org/10.1007/s100960000325 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960000325 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luzzati R. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut NATIONALLICENCE 700 1- Amalfitano G. Laboratory for Microbiology and Virology, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy, IT aut NATIONALLICENCE 700 1- Lazzarini L. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut NATIONALLICENCE 700 1- Soldani F. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut NATIONALLICENCE 700 1- Bellino S. Informa, Via dei Magazzini Generali 31, 00154 Rome, Italy, IT aut NATIONALLICENCE 700 1- Solbiati M. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut NATIONALLICENCE 700 1- Danzi M. C. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut NATIONALLICENCE 700 1- Vento S. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut NATIONALLICENCE 700 1- Todeschini G. Cancer Clinical Centre, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy, IT aut NATIONALLICENCE 700 1- Vivenza C. Intensive Care Services, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy, IT aut NATIONALLICENCE 700 1- Concia E. Department of Infectious Diseases, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy e-mail: luzzati@borgotrento.univr.it, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer