caa a22 4500 475832582 CHVBK 20180406123844.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s100960050499 doi (NATIONALLICENCE)springer-10.1007/s100960050499 Higher Short-Term Virologic Efficacy of Three-Class Versus Two-Class Highly Active Antiretroviral Salvage Therapy in HIV-Infected Patients [Elektronische Daten] [F. Baldanti, S. Paolucci, R. Maserati, F. Maggiolo, A. Pan, F. Castelli, R. Gulminetti, G. Comolli, A. Chiesa, G. Gerna]  The efficacy of two-class versus three-class antiretroviral salvage treatment was analyzed retrospectively in 63 HIV-infected patients in whom highly active antiretroviral therapy failed. Twenty-eight patients (group A) received two-class therapy, and 35 patients (group B) received three-class therapy. After 3 months of treatment, a significantly greater proportion of patients in group B (23/35, 65.7%) than in group A (8/28, 28.5%) showed a ≥1 log10 decrease in the plasma HIV RNA level (P=0.0034). However, after 9-12 months, 12 of 23 (52.1%) group B responders showed viral load rebound. The results were partially explained by the finding that, at baseline, the great majority (21/27, 77.7%) of group A patients showed mutations conferring resistance to all drugs administered, whereas in group B patients' susceptibility to at least two drug classes was retained. However, after 9-12 months of therapy, most (18/20, 90%) of the short-term responders in group B showed emergence of additional mutations that hampered long-term response. Springer-Verlag Berlin Heidelberg, 2000 Baldanti F. Servizio di Virologia and Laboratori Sperimentali di Ricerca, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy, IT aut Paolucci S. Servizio di Virologia, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy e-mail: g.gerna@smatteo.pv.it, IT aut Maserati R. Istituto di Malattie Infettive, Università di Pavia, 27100 Pavia, Italy, IT aut Maggiolo F. Divisione di Malattie Infettive, Ospedali Riuniti di Bergamo, 24100 Bergamo, Italy, IT aut Pan A. Divisione di Malattie Infettive, Presidio Ospedaliero Cremonese, 26100 Cremona, Italy, IT aut Castelli F. Istituto di Malattie Infettive e Tropicali, Università di Brescia, 25100 Brescia, Italy, IT aut Gulminetti R. Servizio di Virologia and Laboratori Sperimentali di Ricerca, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy, IT aut Comolli G. Servizio di Virologia and Laboratori Sperimentali di Ricerca, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy, IT aut Chiesa A. Servizio di Virologia, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy e-mail: g.gerna@smatteo.pv.it, IT aut Gerna G. Servizio di Virologia, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy e-mail: g.gerna@smatteo.pv.it, IT aut https://doi.org/10.1007/s100960050499 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050499 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baldanti F. Servizio di Virologia and Laboratori Sperimentali di Ricerca, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy, IT aut NATIONALLICENCE 700 1- Paolucci S. Servizio di Virologia, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy e-mail: g.gerna@smatteo.pv.it, IT aut NATIONALLICENCE 700 1- Maserati R. Istituto di Malattie Infettive, Università di Pavia, 27100 Pavia, Italy, IT aut NATIONALLICENCE 700 1- Maggiolo F. Divisione di Malattie Infettive, Ospedali Riuniti di Bergamo, 24100 Bergamo, Italy, IT aut NATIONALLICENCE 700 1- Pan A. Divisione di Malattie Infettive, Presidio Ospedaliero Cremonese, 26100 Cremona, Italy, IT aut NATIONALLICENCE 700 1- Castelli F. Istituto di Malattie Infettive e Tropicali, Università di Brescia, 25100 Brescia, Italy, IT aut NATIONALLICENCE 700 1- Gulminetti R. Servizio di Virologia and Laboratori Sperimentali di Ricerca, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy, IT aut NATIONALLICENCE 700 1- Comolli G. Servizio di Virologia and Laboratori Sperimentali di Ricerca, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy, IT aut NATIONALLICENCE 700 1- Chiesa A. Servizio di Virologia, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy e-mail: g.gerna@smatteo.pv.it, IT aut NATIONALLICENCE 700 1- Gerna G. Servizio di Virologia, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy e-mail: g.gerna@smatteo.pv.it, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer