caa a22 4500 475832655 CHVBK 20180406123844.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s100960050491 doi (NATIONALLICENCE)springer-10.1007/s100960050491 Nosocomial Cluster of Candida lipolytica Fungemia in Pediatric Patients [Elektronische Daten] [J. H. Shin, H. Kook, D. H. Shin, T. J. Hwang, M. Kim, S. P. Suh, D. W. Ryang]  Candida lipolytica has rarely been reported as a human pathogen. An apparent outbreak of Candida lipolytica fungemia (n=5 cases) occurred in a pediatric ward over a 9-week period. The five patients infected were hospitalized in three adjacent rooms and cared for by the same healthcare workers. The index patient had central venous catheter-related fungemia, whereas the second patient, who was in the adjacent single room, had transient fungemia. Three additional cases of fungemia occurred in patients with hematological disorders who shared the same room; all three patients had central venous catheters and had been receiving oral fluconazole prophylaxis (50 mg/day for more than 3 weeks) at the time of infection. In vitro susceptibility testing of the strains showed that the MIC of fluconazole for all the isolates was 32 μg/ml. Random amplified polymorphic DNA analysis provided evidence of the clonal origin of the isolates, but the source of the outbreak was not identified. All four patients with persistent fungemia were successfully treated via catheter removal or empiric amphotericin B treatment. This outbreak shows the potential for the nosocomial epidemic transmission of Candida lipolytica. Springer-Verlag Berlin Heidelberg, 2000 Shin J. H. Department of Clinical Pathology, Chonnam University Medical School, 8 Hakdong, Donggu, Kwangju 501-757, Korea e-mail: shinjh@chonnam.chonnam.ac.kr, KR aut Kook H. Department of Pediatrics, Chonnam University Medical School, Kwangju 501-757, Korea, KR aut Shin D. H. Department of Internal Medicine, Chonnam University Medical School, Kwangju 501-757, Korea, KR aut Hwang T. J. Department of Pediatrics, Chonnam University Medical School, Kwangju 501-757, Korea, KR aut Kim M. Department of Clinical Pathology, Chonnam University Medical School, 8 Hakdong, Donggu, Kwangju 501-757, Korea e-mail: shinjh@chonnam.chonnam.ac.kr, KR aut Suh S. P. Department of Clinical Pathology, Chonnam University Medical School, 8 Hakdong, Donggu, Kwangju 501-757, Korea e-mail: shinjh@chonnam.chonnam.ac.kr, KR aut Ryang D. W. Department of Clinical Pathology, Chonnam University Medical School, 8 Hakdong, Donggu, Kwangju 501-757, Korea e-mail: shinjh@chonnam.chonnam.ac.kr, KR aut https://doi.org/10.1007/s100960050491 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050491 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shin J. H. Department of Clinical Pathology, Chonnam University Medical School, 8 Hakdong, Donggu, Kwangju 501-757, Korea e-mail: shinjh@chonnam.chonnam.ac.kr, KR aut NATIONALLICENCE 700 1- Kook H. Department of Pediatrics, Chonnam University Medical School, Kwangju 501-757, Korea, KR aut NATIONALLICENCE 700 1- Shin D. H. Department of Internal Medicine, Chonnam University Medical School, Kwangju 501-757, Korea, KR aut NATIONALLICENCE 700 1- Hwang T. J. Department of Pediatrics, Chonnam University Medical School, Kwangju 501-757, Korea, KR aut NATIONALLICENCE 700 1- Kim M. Department of Clinical Pathology, Chonnam University Medical School, 8 Hakdong, Donggu, Kwangju 501-757, Korea e-mail: shinjh@chonnam.chonnam.ac.kr, KR aut NATIONALLICENCE 700 1- Suh S. P. Department of Clinical Pathology, Chonnam University Medical School, 8 Hakdong, Donggu, Kwangju 501-757, Korea e-mail: shinjh@chonnam.chonnam.ac.kr, KR aut NATIONALLICENCE 700 1- Ryang D. W. Department of Clinical Pathology, Chonnam University Medical School, 8 Hakdong, Donggu, Kwangju 501-757, Korea e-mail: shinjh@chonnam.chonnam.ac.kr, KR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer