caa a22 4500 475832817 CHVBK 20180406123845.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s100960050445 doi (NATIONALLICENCE)springer-10.1007/s100960050445 Effect of Administering Short-Course, Standardized Regimens in Individuals Infected with Drug-Resistant Mycobacterium tuberculosis Strains [Elektronische Daten] [J. J. Furin, M. C. Becerra, S. S. Shin, J. Y. Kim, J. Bayona, P. E. Farmer]  Presented here are the cases of three siblings with multidrug-resistant tuberculosis who demonstrated increased antituberculous-drug resistance during the periods in which they received standard regimens of directly observed, short-course chemotherapy that were administered before the susceptibility patterns of their Mycobacterium tuberculosis isolates had been checked. More specifically, they acquired resistance to drugs they received as part of ineffective standard treatment and retreatment regimens. Development of antituberculous-drug resistance through inadvertent, inadequate therapy appears to be the most likely explanation for the increased resistance seen in these three patients. Springer-Verlag Berlin Heidelberg, 2000 Furin J. J. Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA e-mail: JENFURIN@AOL.COM, US aut Becerra M. C. Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA e-mail: JENFURIN@AOL.COM, US aut Shin S. S. Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA e-mail: JENFURIN@AOL.COM, US aut Kim J. Y. Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA e-mail: JENFURIN@AOL.COM, US aut Bayona J. Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA e-mail: JENFURIN@AOL.COM, US aut Farmer P. E. Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA e-mail: JENFURIN@AOL.COM, US aut https://doi.org/10.1007/s100960050445 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050445 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Furin J. J. Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA e-mail: JENFURIN@AOL.COM, US aut NATIONALLICENCE 700 1- Becerra M. C. Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA e-mail: JENFURIN@AOL.COM, US aut NATIONALLICENCE 700 1- Shin S. S. Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA e-mail: JENFURIN@AOL.COM, US aut NATIONALLICENCE 700 1- Kim J. Y. Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA e-mail: JENFURIN@AOL.COM, US aut NATIONALLICENCE 700 1- Bayona J. Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA e-mail: JENFURIN@AOL.COM, US aut NATIONALLICENCE 700 1- Farmer P. E. Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA e-mail: JENFURIN@AOL.COM, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer