caa a22 4500 475833015 CHVBK 20180406123845.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s100960000379 doi (NATIONALLICENCE)springer-10.1007/s100960000379 Effect of Patient Adherence to Antiretroviral Therapy on CD4+ Cell Count, HIV-1 RNA, and Serum Concentrations of Tumor Necrosis Factor and its Soluble Receptors [Elektronische Daten] [J. A. Girón-González, A. López-Sánchez, J. Elvira, E. Perez, C. Fernández-Gutiérrez]  A 1-year prospective analysis of patient adherence to antiretroviral therapy (zidovudine plus zalcitabine [55 patients] or zidovudine plus zalcitabine plus saquinavir [32 patients]) was performed in human immunodeficiency virus (HIV)-infected patients attended at a tertiary care hospital. Adherence to therapy was measured jointly by pharmacy records, patients' self-recording, and an increase in mean corpuscular volume. Likewise, the effects of therapy on clinical parameters, HIV load, CD4+ cell count, and serum levels of tumor necrosis factor alpha (TNF-α) and its soluble receptors were analyzed. Twenty-seven patients of those on a double-agent regimen and 12 of those on a triple-agent regimen adhered to the treatment. Ten opportunistic events occurred in noncompliant patients versus none in compliant individuals. A significant increase in CD4+ cell count and a decrease in HIV viral load were observed only in patients who adhered to therapy. TNF and its soluble receptors remained elevated at the end of follow-up, even in patients in whom the HIV viral load decreased to <400 copies/ml. In conclusion, adherence to therapy must be considered a major factor influencing the results of antiretroviral therapy. Although these treatments have been demonstrated to be efficacious, they are not able to normalize the immune activation markers. These data suggest a suboptimal effect of antiretroviral therapy on the eradication of HIV-1. Springer-Verlag Berlin Heidelberg, 2000 Girón-González J. A. Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas, Hospital Universitario Puerta del Mar, Facultad de Medicina, Avenida Ana de Viya 21, 11009 Cádiz, Spain e-mail: epgei@comcadiz.es Tel.: +34-956-242879 Fax: +34-956-242879, ES aut López-Sánchez A. Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas, Hospital Universitario Puerta del Mar, Facultad de Medicina, Avenida Ana de Viya 21, 11009 Cádiz, Spain e-mail: epgei@comcadiz.es Tel.: +34-956-242879 Fax: +34-956-242879, ES aut Elvira J. Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas, Hospital Universitario Puerta del Mar, Facultad de Medicina, Avenida Ana de Viya 21, 11009 Cádiz, Spain e-mail: epgei@comcadiz.es Tel.: +34-956-242879 Fax: +34-956-242879, ES aut Perez E. Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas, Hospital Universitario Puerta del Mar, Facultad de Medicina, Avenida Ana de Viya 21, 11009 Cádiz, Spain e-mail: epgei@comcadiz.es Tel.: +34-956-242879 Fax: +34-956-242879, ES aut Fernández-Gutiérrez C. Servicio de Microbiología, Hospital Universitario Puerta del Mar, Facultad de Medicina, Cádiz, Spain, ES aut https://doi.org/10.1007/s100960000379 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960000379 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Girón-González J. A. Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas, Hospital Universitario Puerta del Mar, Facultad de Medicina, Avenida Ana de Viya 21, 11009 Cádiz, Spain e-mail: epgei@comcadiz.es Tel.: +34-956-242879 Fax: +34-956-242879, ES aut NATIONALLICENCE 700 1- López-Sánchez A. Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas, Hospital Universitario Puerta del Mar, Facultad de Medicina, Avenida Ana de Viya 21, 11009 Cádiz, Spain e-mail: epgei@comcadiz.es Tel.: +34-956-242879 Fax: +34-956-242879, ES aut NATIONALLICENCE 700 1- Elvira J. Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas, Hospital Universitario Puerta del Mar, Facultad de Medicina, Avenida Ana de Viya 21, 11009 Cádiz, Spain e-mail: epgei@comcadiz.es Tel.: +34-956-242879 Fax: +34-956-242879, ES aut NATIONALLICENCE 700 1- Perez E. Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas, Hospital Universitario Puerta del Mar, Facultad de Medicina, Avenida Ana de Viya 21, 11009 Cádiz, Spain e-mail: epgei@comcadiz.es Tel.: +34-956-242879 Fax: +34-956-242879, ES aut NATIONALLICENCE 700 1- Fernández-Gutiérrez C. Servicio de Microbiología, Hospital Universitario Puerta del Mar, Facultad de Medicina, Cádiz, Spain, ES aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer