caa a22 4500 47583318X CHVBK 20180406123846.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1007891121240 doi (NATIONALLICENCE)springer-10.1023/A:1007891121240 Benefit of Antihypertensive Treatment in the diabetic patients enrolled in the Systolic Hypertension in Europe (Syst-Eur) Trial [Elektronische Daten] [Jerzy Gasowski, Willem Birkenhäger, Jan Staessen, Peter de Leeuw] In this review we attempt to determine the role of calcium channel blockers in preventing cardiovascular sequelae in patients with both hypertension and diabetes mellitus. The data have been collected from three sources: post-hoc analyses of subgroups of diabetic patients in placebo-controlled hypertension trials (SHEP, Syst-Eur, Syst-China); stepped-care blood pressure-oriented trials (HOT, UKPDS); and comparative trials focusing primarily on metabolic aspects and intermediate endpoints (ABCD, FACET). On balance, the data seem to indicate that long-acting calcium channel blockers score remarkably well in preventing cardiovascular complications in diabetic hypertensive patients. Kluwer Academic Publishers, 2000 hypertension nationallicence diabetes nationallicence prospective antihypertensive trials nationallicence trial endpoints nationallicence dihydropiridine-type long-acting calcium channel blockers nationallicence ACE inhibitors nationallicence diuretics nationallicence beta-blockers nationallicence Gasowski Jerzy Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium aut Birkenhäger Willem Erasmus University Rotterdam, The Netherlands aut Staessen Jan Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium aut de Leeuw Peter Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/1(2000-02-01), 49-53 0920-3206 14:1<49 2000 14 10557 https://doi.org/10.1023/A:1007891121240 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007891121240 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gasowski Jerzy Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Birkenhäger Willem Erasmus University Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Staessen Jan Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- de Leeuw Peter Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/1(2000-02-01), 49-53 0920-3206 14:1<49 2000 14 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer