caa a22 4500 475833236 CHVBK 20180406123846.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1007866102585 doi (NATIONALLICENCE)springer-10.1023/A:1007866102585 Role of K+ATP Channels in Ischemic Preconditioning and Cardioprotection [Elektronische Daten] [Dirk Duncker, Pieter Verdouw] Summary. Since the phenomenon of ischemic preconditioning was first described some 15 years ago, interest in strategies aimed at reducing infarct size has increased. During the past 10 years, investigations into the mechanism of ischemic preconditioning have clearly demonstrated the cardioprotective effect of K+ ATP channel opening. Thus, K+ ATP channel activation has been shown to be involved in this protection by a variety of stimuli, including a brief period of complete ischemia (classic ischemic preconditioning) or a partial coronary artery occlusion. In addition, ischemia in remote organs and nonischemic stimuli in the heart such as ventricular pacing, stretch, and heat stress also confer protection via K+ ATP channel activation. Pharmacological agents that open K+ ATP channels reduce infarct size, but K+ ATP channel opening must occur prior to or early during the sustained infarct-producing coronary artery occlusion, while the degree and memory of cardioprotection are less than those produced by classic ischemic preconditioning. Although the exact mechanism by which K+ ATP channel activation protects is still incompletely understood, recent studies indicate a role for the mitochondrial K+ ATP channels. Before K+ ATP channel opening can be employed in patients at increased risk of developing myocardial infarction (e.g., unstable angina), it is mandatory to determine whether tolerance (tachyphylaxia) occurs with repeated administration of K+ ATP channel openers in a fashion similar to what occurs with ischemic preconditioning. Kluwer Academic Publishers, 2000 K+ATP channels nationallicence ischemic preconditioning nationallicence cardioprotection nationallicence infarct size nationallicence remote preconditioning nationallicence cardiac pacing nationallicence myocardial stretch nationallicence tolerance nationallicence memory nationallicence Duncker Dirk Experimental Cardiology, Thoraxcenter, Erasmus University Rotterdam, Rotterdam, The Netherlands aut Verdouw Pieter Experimental Cardiology, Thoraxcenter, Erasmus University Rotterdam, Rotterdam, The Netherlands aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/1(2000-02-01), 7-16 0920-3206 14:1<7 2000 14 10557 https://doi.org/10.1023/A:1007866102585 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007866102585 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Duncker Dirk Experimental Cardiology, Thoraxcenter, Erasmus University Rotterdam, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Verdouw Pieter Experimental Cardiology, Thoraxcenter, Erasmus University Rotterdam, Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/1(2000-02-01), 7-16 0920-3206 14:1<7 2000 14 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer