caa a22 4500 475833309 CHVBK 20180406123846.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1007875100562 doi (NATIONALLICENCE)springer-10.1023/A:1007875100562 Quinaprilat-Induced Vasodilatation in Forearm Vasculature of Patients with Essential Hypertension: Comparison with Enalaprilat [Elektronische Daten] [A.J.H.M. Houben, A.A. Kroon, C.H.A. de Haan, M.J.M.J. Fuss-Lejeune, P.W. de Leeuw] The aim of the present study was to assess the possible differences in hemodynamic and neurohumoral responses to local ACE inhibition in the human forearm of patients with essential hypertension with either quinaprilat or enalaprilat. Forearm vascular responses to infusion of quinaprilat or enalaprilat (0.5 μg/dL/min) into the brachial artery were studied in 12 male patients with essential hypertension. The experiments were performed in a randomized, double-blind, crossover fashion. Before and during ACE inhibition, the vasoconstrictor response to four cumulative doses of angiotensin I (Ang I) was studied. Forearm blood flow was assessed using venous occlusion plethysmography. Local quinaprilat infusion induced a more rapid (even after 15 minutes; median vasodilation quinaprilat 29% vs. enalaprilat −1%, P > 0.02) and longer lasting forearm vaso-dilation as compared with enalaprilat. After 15 minutes of local ACE inhibition, the vasoconstrictor response to Ang I was completely blocked by both ACE inhibitors. We conclude that in patients with essential hypertension quinaprilat induces a more rapid and longer lasting vasodilatation than enalaprilat. These effects of quinaprilat are possibly related to its higher affinity for vascular ACE. On the other hand, the fact that these effects of quinaprilat were observed despite a similar degree of ACE inhibition as during enalaprilat may suggest that quinaprilat directly stimulates another vasodilatating mechanism. Kluwer Academic Publishers, 2000 ACE inhibitors nationallicence tissue ACE nationallicence forearm blood flow nationallicence essential hypertension nationallicence quinaprilat nationallicence enalaprilat nationallicence Houben A.J.H.M. Department of Internal Medicine, University Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands aut Kroon A.A. Department of Internal Medicine, University Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands aut de Haan C.H.A. Department of Internal Medicine, University Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands aut Fuss-Lejeune M.J.M.J. Department of Internal Medicine, University Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands aut de Leeuw P.W. Department of Internal Medicine, University Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/6(2000-12-01), 657-663 0920-3206 14:6<657 2000 14 10557 https://doi.org/10.1023/A:1007875100562 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007875100562 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Houben A.J.H.M. Department of Internal Medicine, University Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Kroon A.A. Department of Internal Medicine, University Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- de Haan C.H.A. Department of Internal Medicine, University Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Fuss-Lejeune M.J.M.J. Department of Internal Medicine, University Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- de Leeuw P.W. Department of Internal Medicine, University Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/6(2000-12-01), 657-663 0920-3206 14:6<657 2000 14 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer