caa a22 4500 475833333 CHVBK 20180406123846.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1007846311040 doi (NATIONALLICENCE)springer-10.1023/A:1007846311040 Combined Treatment with Ramipril and Metoprolol Prevents Changes in the Creatine Kinase Isoenzyme System and Improves Hemodynamic Function in Rat Hearts after Myocardial Infarction [Elektronische Daten] [Heinz Theres, Kay-Dietrich Wagner, Dietrich Romberg, Cornelia Feig, Steffen Strube, Kate Leiterer, Joachim Günther, Karl Stangl, Gert Baumann, Ingolf Schimke] Beneficial effects of monotherapy with ACE inhibitors or beta-blockers on hemodynamic function after myocardial infarction are well known. Until now, the effects of combined treatment on cardiac function and energy metabolism have been poorly described. This study examines the effects of combined ramipril and metoprolol treatment on the creatine kinase (CK) system and hemodynamic function in rats after infarction. Wistar rats with experimental infarction were randomized for treatment with ramipril (R), metoprolol (M), combined treatment (MR), or placebo (P). Sham-operated (SO) animals served as controls. After 6 weeks, we assayed for CK isoenzymes and performed hemodynamic measurements. In P versus SO, left ventricular systolic pressures (dp/dtmax and dp/dtmin) diminished, whereas left ventricular end-diastolic pressure (LVEDP) increased. Decreased total CK activity and mitochondrial CK isoenzyme, increased CK-MB, and increased CK-BB isoenzymes were measured in P versus SO. With infarct size ≤45%, mitochondrial CK increased in M and R versus P. Combined treatment had an additional enhancing effect on mitochondrial CK isoenzyme level versus M and R, decreased LVEDP versus P, as well as increased dp/dtmax and dp/dtmin versus R. These results provide evidence of an interaction between normalization of energy metabolism and improvement in cardiac function due to a combination of ACE inhibition and beta blockade after myocardial infarction. Kluwer Academic Publishers, 2000 ACE inhibition nationallicence beta blockade nationallicence creatine kinase system nationallicence hemodynamics nationallicence myocardial infarction nationallicence Theres Heinz Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut Wagner Kay-Dietrich Institute of Physiology, Internal Medicine, Humboldt University (Charité), Berlin, Germany aut Romberg Dietrich Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut Feig Cornelia Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut Strube Steffen Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut Leiterer Kate Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut Günther Joachim Institute of Physiology, Humboldt University (Charité), Berlin, Germany aut Stangl Karl Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut Baumann Gert Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut Schimke Ingolf Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/6(2000-12-01), 597-606 0920-3206 14:6<597 2000 14 10557 https://doi.org/10.1023/A:1007846311040 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007846311040 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Theres Heinz Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut NATIONALLICENCE 700 1- Wagner Kay-Dietrich Institute of Physiology, Internal Medicine, Humboldt University (Charité), Berlin, Germany aut NATIONALLICENCE 700 1- Romberg Dietrich Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut NATIONALLICENCE 700 1- Feig Cornelia Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut NATIONALLICENCE 700 1- Strube Steffen Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut NATIONALLICENCE 700 1- Leiterer Kate Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut NATIONALLICENCE 700 1- Günther Joachim Institute of Physiology, Humboldt University (Charité), Berlin, Germany aut NATIONALLICENCE 700 1- Stangl Karl Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut NATIONALLICENCE 700 1- Baumann Gert Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut NATIONALLICENCE 700 1- Schimke Ingolf Clinic for Internal Medicine, Humboldt University (Charité), Berlin, Germany aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/6(2000-12-01), 597-606 0920-3206 14:6<597 2000 14 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer