caa a22 4500 47583335X CHVBK 20180406123847.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1007819015583 doi (NATIONALLICENCE)springer-10.1023/A:1007819015583 Early Experience with Intravascular Ultrasound in Evaluating the Effect of Statins on Femoropopliteal Arterial Disease: Hypothesis-Generating Observations in Humans [Elektronische Daten] [Tjebbe Hagenaars, Elma Gussenhoven, Steven Kranendonk, Jan Blankensteijn, Jan Honkoop, Edwin van der Linden, Aad van der Lugt] The purpose of this study was to compare the vascular response seen with intravascular ultrasound (IVUS) at 1-year follow-up between statin-treated and non-statin-treated patients. Patients (n=10) undergoing percutaneous transluminal angioplasty (PTA) of the femoropopliteal artery were studied with IVUS immediately after PTA and at 1-year follow-up. In nondilated matched vascular segments, the change in lumen, vessel, and plaque volume was assessed. In balloon-dilated matched vascular segments, the change in lumen, vessel, and plaque area was assessed. A comparison was made between statin-treated (n=5) and non-statin-treated patients (n=5) in lumen, vessel, and plaque changes. At follow-up, both statin-treated and non-statin-treated patients showed a similar increase in plaque volume at the nondilated segment (+4% and +2%, respectively). In statin-treated patients the plaque volume increase was compensated by an increase in vessel volume (+2%), resulting in an increase in lumen volume (+1%). In non-statin-treated patients, on the other hand, the increase in plaque volume was associated with a decrease in vessel volume (−2%), resulting in a decrease in lumen volume (−4%). At the balloon-dilated segment a similar trend in changes of lumen, vessel, and plaque was encountered. Differences between both groups of patients were not statistically significant. Despite the nonsignificant nature of the observation, this small retrospective IVUS study may generate the hypothesis that statin therapy may contribute to superior long-term lumen dimensions by inducing positive vascular remodeling both in nondilated and balloon-dilated vascular segments. Kluwer Academic Publishers, 2000 intravascular ultrasound nationallicence atherosclerosis nationallicence progression/regression nationallicence statin nationallicence peripheral arteries nationallicence Hagenaars Tjebbe Departments of Cardiology and Interuniversity Cardiology Institute, The Netherlands aut Gussenhoven Elma Departments of Cardiology and Interuniversity Cardiology Institute, The Netherlands aut Kranendonk Steven Departments of Twee Steden Hospital, Tilburg, The Netherlands aut Blankensteijn Jan Departments of University Hospital, Utrecht, The Netherlands aut Honkoop Jan Departments of Cardiology, The Netherlands aut van der Linden Edwin Departments of Leiden University Medical Center, The Netherlands aut van der Lugt Aad Departments of Radiology, Erasmus Medical Center Rotterdam, The Netherlands aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/6(2000-12-01), 635-641 0920-3206 14:6<635 2000 14 10557 https://doi.org/10.1023/A:1007819015583 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007819015583 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hagenaars Tjebbe Departments of Cardiology and Interuniversity Cardiology Institute, The Netherlands aut NATIONALLICENCE 700 1- Gussenhoven Elma Departments of Cardiology and Interuniversity Cardiology Institute, The Netherlands aut NATIONALLICENCE 700 1- Kranendonk Steven Departments of Twee Steden Hospital, Tilburg, The Netherlands aut NATIONALLICENCE 700 1- Blankensteijn Jan Departments of University Hospital, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Honkoop Jan Departments of Cardiology, The Netherlands aut NATIONALLICENCE 700 1- van der Linden Edwin Departments of Leiden University Medical Center, The Netherlands aut NATIONALLICENCE 700 1- van der Lugt Aad Departments of Radiology, Erasmus Medical Center Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/6(2000-12-01), 635-641 0920-3206 14:6<635 2000 14 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer