caa a22 4500 475833430 CHVBK 20180406123847.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1023/A:1007834708642 doi (NATIONALLICENCE)springer-10.1023/A:1007834708642 Long-Term Cardiovascular Effects of High "Osteoprotective” Dose Levels of 17β-Estradiol in Spontaneously Hypertensive Rats [Elektronische Daten] [Jacques Blacher, Hubert Dabire, Jean Pomies, Michel Safar, Michael Stimpel] The effects of estrogen replacement therapy in menopausal women are more obvious on bones than on the cardiovascular system. The optimal estrogen dosage may differ in these different parts of the body. In hypertensive rats, low doses have been shown to reduce arterial collagen and stiffness, whereas higher dosages are required for osteoprotection. From 4 to 20 weeks of age, female spontaneously hypertensive rats (SHRs) were divided into four groups: without ovariectomy, under placebo or 17β-estradiol (10 μg/kg/day), and with ovariectomy under either placebo or 17β-estradiol (same dosage). Serial tail systolic blood pressure measurements were performed, and histomorphometry of the thoracic aorta was determined at the end of the study. Under estrogen, blood pressure was unchanged, whereas the aortic wall-to-lumen ratio was increased, particularly in the presence of ovariectomy. The elastin to collagen ratio was significantly decreased, due both to a decrease in elastin and an increase in collagen density, with no change in media thickness. The latter findings were not observed when ovariectomy was performed. Independent of changes in wall stress, high-dose estrogen increases the aortic extracellular matrix in female SHRs. This increase may be reversed in the presence of ovariectomy, suggesting that estrogen was not the only gonadal factor responsible for altered vascular structure and function. Kluwer Academic Publishers, 2000 female spontaneously hypertensive rats nationallicence estrogens nationallicence arterial stiffness nationallicence Blacher Jacques Department of Internal Medicine, Broussais Hospital, and INSERM U337, Paris, France aut Dabire Hubert Department of Internal Medicine, Broussais Hospital, and INSERM U337, Paris, France aut Pomies Jean Department of Internal Medicine, Broussais Hospital, and INSERM U337, Paris, France aut Safar Michel Department of Internal Medicine, Broussais Hospital, and INSERM U337, Paris, France aut Stimpel Michael Medical School, University of Cologne, Germany aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/3(2000-03-01), 303-307 0920-3206 14:3<303 2000 14 10557 https://doi.org/10.1023/A:1007834708642 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007834708642 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blacher Jacques Department of Internal Medicine, Broussais Hospital, and INSERM U337, Paris, France aut NATIONALLICENCE 700 1- Dabire Hubert Department of Internal Medicine, Broussais Hospital, and INSERM U337, Paris, France aut NATIONALLICENCE 700 1- Pomies Jean Department of Internal Medicine, Broussais Hospital, and INSERM U337, Paris, France aut NATIONALLICENCE 700 1- Safar Michel Department of Internal Medicine, Broussais Hospital, and INSERM U337, Paris, France aut NATIONALLICENCE 700 1- Stimpel Michael Medical School, University of Cologne, Germany aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/3(2000-03-01), 303-307 0920-3206 14:3<303 2000 14 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer