caa a22 4500 475833511 CHVBK 20180406123847.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1023/A:1007826506825 doi (NATIONALLICENCE)springer-10.1023/A:1007826506825 Comparison of Fentanyl and Droperidol Mixture (Neuroleptanalgesia II) with Morphine on Clinical Outcomes in Unstable Angina Patients [Elektronische Daten] [Piotr Burduk, Przemysław Guzik, Maria Piechocka, Marek Bronisz, Andrzej Rożek, Maciej Jazdon, Michael Jordan] The objective of the study was to compare the influence of a fentanyl and droperidol mixture (neuroleptanalgesia) with morphine on the in-hospital instability, development of acute myocardial infarction (AMI), and mortality during a 30-day and 12-month follow-up in unstable angina patients. The study was performed in 112 unstable angina patients. In addition to standard therapy for unstable angina (aspirin, heparin, nitroglycerin, and oxygen), 53 patients (63.2 ± 9.7 years; 32 males) were randomized to receive neuroleptanalgesia (0.025 mg fentanyl and 1.25 mg droperidol in a volume of 1 mL) and 59 patients (58.6 ± 11.5 years; 41 males) to receive morphine. Neuroleptanalgesia was started IV with 2 mL and could be followed by 1 mL every 4 hours. Morphine was started IV with 10 mg and could be followed by 5 mg every 4 hours up to angina resolution during 24 hours of hospitalization. Another 1 mL of neuroleptanalgesia or 5 mg of morphine could be administered on demand if angina lasted or reappeared earlier than the next scheduled dose. Odds ratios with 95% confidence intervals (95% CI) adjusted for the age, sex, smoking, previous myocardial infarction, and hypertension were evaluated for all study outcomes. The odds ratios for clinical in-hospital instability (5.93, 95% CI: 2.49-14.15; P = 0.0001), 12-month AMI development (3.57, 95% CI: 1.51-8.45; P = 0.0038), and 12-month mortality (6.00, 95% CI: 1.63-22.09;P = 0.0070) were significantly increased in the neuroleptanalgesia group compared with the patients on morphine. It is concluded that neuroleptanalgesia negatively influences disease course, AMI development, and total mortality in unstable angina patients. Kluwer Academic Publishers, 2000 unstable angina nationallicence analgesics nationallicence fentanyl nationallicence droperidol nationallicence neuroleptanalgesia nationallicence morphine nationallicence recurrent ischemia nationallicence acute myocardial infarction nationallicence mortality nationallicence Burduk Piotr Division of Cardiology, Ministry of Internal Affair Hospital in Bydgoszcz, Markwarta, Poland aut Guzik Przemysław Division of Cardiology-Intensive Therapy, University School of Medical Sciences in Poznań, Poznań, Poland aut Piechocka Maria Division of Cardiology, Ministry of Internal Affair Hospital in Bydgoszcz, Markwarta, Poland aut Bronisz Marek Division of Cardiology, Ministry of Internal Affair Hospital in Bydgoszcz, Markwarta, Poland aut Rożek Andrzej Division of Cardiology, Ministry of Internal Affair Hospital in Bydgoszcz, Markwarta, Poland aut Jazdon Maciej Division of Cardiology, Ministry of Internal Affair Hospital in Bydgoszcz, Markwarta, Poland aut Jordan Michael Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/3(2000-03-01), 259-269 0920-3206 14:3<259 2000 14 10557 https://doi.org/10.1023/A:1007826506825 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007826506825 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Burduk Piotr Division of Cardiology, Ministry of Internal Affair Hospital in Bydgoszcz, Markwarta, Poland aut NATIONALLICENCE 700 1- Guzik Przemysław Division of Cardiology-Intensive Therapy, University School of Medical Sciences in Poznań, Poznań, Poland aut NATIONALLICENCE 700 1- Piechocka Maria Division of Cardiology, Ministry of Internal Affair Hospital in Bydgoszcz, Markwarta, Poland aut NATIONALLICENCE 700 1- Bronisz Marek Division of Cardiology, Ministry of Internal Affair Hospital in Bydgoszcz, Markwarta, Poland aut NATIONALLICENCE 700 1- Rożek Andrzej Division of Cardiology, Ministry of Internal Affair Hospital in Bydgoszcz, Markwarta, Poland aut NATIONALLICENCE 700 1- Jazdon Maciej Division of Cardiology, Ministry of Internal Affair Hospital in Bydgoszcz, Markwarta, Poland aut NATIONALLICENCE 700 1- Jordan Michael Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/3(2000-03-01), 259-269 0920-3206 14:3<259 2000 14 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer