caa a22 4500 475833570 CHVBK 20180406123847.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1007808131419 doi (NATIONALLICENCE)springer-10.1023/A:1007808131419 Should Dietary Salt Restriction Be a Basic Component of Antihypertensive Therapy? [Elektronische Daten] [Niels Graudal, Anders Galløe] The general intake of salt (sodium chloride) is much higher than the recommended allowances, in part because of added salt in food industry processed food. However, population studies have not been able to show an association between salt intake and unfavorable health outcome. Based on population studies and randomized studies, the effect of an extreme salt reduction of 100 mmol on blood pressure in hypertensive persons is about one third of the effect of antihypertensive medications. This effect-size estimate is based on single measurements of blood pressure and is probably overestimated compared with 24-hour blood pressure measurements. Salt reduction has effects on heart rate and serum levels of renin, aldosterone, catecholamines, and lipids that may be unfavorable. Because of insufficient compliance, extreme salt reduction can only be obtained if salt in food industry processed food is eliminated. The full consequences of such elimination are not known. Other nonpharmacological interventions, such as weight reduction and diets including fruits, vegetables, and low-fat dairy foods, are probably easier to implement and more effective to decrease blood pressure than salt reduction. Furthermore, salt reduction does not seem to add to the effect size when combined with other nonpharmacological interventions. Salt sensitivity due to sodium channel mutations has been shown in a minority of blacks but not in Caucasians. In conclusion, at present, dietary salt restriction should not be a basic component of antihypertensive therapy. Kluwer Academic Publishers, 2000 diet nationallicence hypertension nationallicence salt nationallicence sodium nationallicence treatment nationallicence Graudal Niels The Tissue Typing Laboratory of the Department of Clinical Immunology, the National University Hospital, University of Copenhagen, Denmark aut Galløe Anders Department of Cardiology P, Gentofte Hospital, University of Copenhagen, Denmark aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/4(2000-06-01), 381-386 0920-3206 14:4<381 2000 14 10557 https://doi.org/10.1023/A:1007808131419 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007808131419 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Graudal Niels The Tissue Typing Laboratory of the Department of Clinical Immunology, the National University Hospital, University of Copenhagen, Denmark aut NATIONALLICENCE 700 1- Galløe Anders Department of Cardiology P, Gentofte Hospital, University of Copenhagen, Denmark aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/4(2000-06-01), 381-386 0920-3206 14:4<381 2000 14 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer