caa a22 4500 475833694 CHVBK 20180406123848.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1007851913672 doi (NATIONALLICENCE)springer-10.1023/A:1007851913672 Robertson J.I.S. Elmbank, Manse Road, Bowling, Glasgow, G60 5AA, Strathclyde, UK aut Which Antihypertensive Drug Classes Have Been Shown to be Beneficial? What Are Their Benefits? A Critique of Hypertension Treatment Trials [Elektronische Daten] [J.I.S. Robertson] Antihypertensive drug treatment trials and meta-analyses thereof have been reviewed. Disturbing inaccuracies and inconsistencies have been exposed. Some commentators have excluded certain trials from consideration for explicit reasons on one occasion, and then unaccountably relaxed their rigor subsequently. Most problematic and notorious have been the varied evaluations of the large American HDFP study, which compared patients allocated to two quite different health care systems, addressed multiple risk factors additional to hypertension, and employed very questionable definitions of nonfatal coronary events. Data from this large and pervasive study especially have polluted several meta-analyses and treatment guidelines. There have been several exaggerated claims of benefit concerning coronary artery disease and all-cause mortality. Kluwer Academic Publishers, 2000 hypertension nationallicence treatment trials nationallicence antihypertensive drugs nationallicence meta-analysis nationallicence Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/4(2000-06-01), 357-366 0920-3206 14:4<357 2000 14 10557 https://doi.org/10.1023/A:1007851913672 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007851913672 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Robertson J.I.S. Elmbank, Manse Road, Bowling, Glasgow, G60 5AA, Strathclyde, UK aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/4(2000-06-01), 357-366 0920-3206 14:4<357 2000 14 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer