caa a22 4500 475833732 CHVBK 20180406123848.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1023/A:1007820919574 doi (NATIONALLICENCE)springer-10.1023/A:1007820919574 T-Type Calcium Channel Blockade in the Management of Chronic Ischemic Heart Disease [Elektronische Daten] [James Marsh, Elliott Antman] The T-Type calcium channel offers a new therapeutic target for teatment of patients with cardiovascular disease. Mibefradil, a T channel blocker, produces heart rate slowing and coronary vasodilatation but without the negative inotropic effect commonly seen when L-Type channel blockers are used. The present study shows Mibefradil prevents ischemic episodes that are and are not preceded by an increase in heart rate. Although Mibefradil has been withdrawn because of multiple drug interactions, new T-Type calcium channel blockers are under development. Kluwer Academic Publishers, 2000 angina pectoris nationallicence calcium channel nationallicence Mibefradil nationallicence T-Type channel nationallicence Marsh James Cardiovascular Division, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan aut Antman Elliott Cardiovascular Division, Department of Internal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/5(2000-10-01), 459-461 0920-3206 14:5<459 2000 14 10557 https://doi.org/10.1023/A:1007820919574 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007820919574 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marsh James Cardiovascular Division, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan aut NATIONALLICENCE 700 1- Antman Elliott Cardiovascular Division, Department of Internal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/5(2000-10-01), 459-461 0920-3206 14:5<459 2000 14 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer