caa a22 4500 475833805 CHVBK 20180406123848.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1023/A:1007845324117 doi (NATIONALLICENCE)springer-10.1023/A:1007845324117 Effect of Long-Term Losartan Administration on Renal Haemodynamics and Function in Hypertensive Patients [Elektronische Daten] [Salvatore Paterna, Gaspare Parrinello, Rosario Scaglione, Renato Costa, Antonina Bova, Vincenzo Palumbo, Antonio Pinto, Pietra Amato, Giuseppe Licata] In this study the efficacy and safety of long-term losartan administration on renal haemodynamics were evaluated in mild to moderate hypertension. After a run-in period with placebo, 18 hypertensives without renal or cardiovascular disease were allocated to losartan (50 mg/die for one year) treatment. Renal haemodynamic measurements included renal plasma flow (ERPF) and glomerular filtration rate (GFR) by standardized radioisotope study. Effective renal blood flow (ERBF), filtration fraction (FF), and renal vascular resistance (RVR) were also calculated. Blood pressure was evaluated monthly, whereas renal haemodynamics and function were detected at baseline and after 6 and 12 months of losartan administration. Losartan induced a significant (p < 0.001) decrease in SBP, DBP, and MBP versus baseline values both at 6 months and at 12 months. In addition a significant decrease in RVR (p < 0.001) and in FF (p < 0.05) was also seen. In addition RVR values at 1 year of treatment were higher than their values at 6 months, but this difference was not significant. Our data indicated that long-term control in blood pressure induced by losartan administration was associated with a maintained renal function after 6 months of treatment, but these favourable effects were attenuated after 1 year of treatment. Kluwer Academic Publishers, 2000 hypertension nationallicence angiotensin receptor antagonist nationallicence renal haemodynamics nationallicence renal function nationallicence Paterna Salvatore Department of Internal Medicine, University of Palermo, Italy aut Parrinello Gaspare Department of Internal Medicine, University of Palermo, Italy aut Scaglione Rosario Department of Internal Medicine, University of Palermo, Italy aut Costa Renato Department of Internal Medicine, University of Palermo, Italy aut Bova Antonina Department of Internal Medicine, University of Palermo, Italy aut Palumbo Vincenzo Department of Internal Medicine, University of Palermo, Italy aut Pinto Antonio Department of Internal Medicine, University of Palermo, Italy aut Amato Pietra Department of Internal Medicine, University of Palermo, Italy aut Licata Giuseppe Department of Internal Medicine, University of Palermo, Italy aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/5(2000-10-01), 529-532 0920-3206 14:5<529 2000 14 10557 https://doi.org/10.1023/A:1007845324117 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007845324117 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paterna Salvatore Department of Internal Medicine, University of Palermo, Italy aut NATIONALLICENCE 700 1- Parrinello Gaspare Department of Internal Medicine, University of Palermo, Italy aut NATIONALLICENCE 700 1- Scaglione Rosario Department of Internal Medicine, University of Palermo, Italy aut NATIONALLICENCE 700 1- Costa Renato Department of Internal Medicine, University of Palermo, Italy aut NATIONALLICENCE 700 1- Bova Antonina Department of Internal Medicine, University of Palermo, Italy aut NATIONALLICENCE 700 1- Palumbo Vincenzo Department of Internal Medicine, University of Palermo, Italy aut NATIONALLICENCE 700 1- Pinto Antonio Department of Internal Medicine, University of Palermo, Italy aut NATIONALLICENCE 700 1- Amato Pietra Department of Internal Medicine, University of Palermo, Italy aut NATIONALLICENCE 700 1- Licata Giuseppe Department of Internal Medicine, University of Palermo, Italy aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 14/5(2000-10-01), 529-532 0920-3206 14:5<529 2000 14 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer