caa a22 4500 475835344 CHVBK 20180406123851.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/BF02515163 doi (NATIONALLICENCE)springer-10.1007/BF02515163 Behavioral reactions of rats and the contents of neurospecific proteins in their brain after single X-ray irradiation [Elektronische Daten] [I. Leshchinskaya, T. Douka, V. Chernaya] We studied the behavior of rats in an open-field test and the contents of neurospecific proteins [neural cell adhesion molecule (NCAM) and glial fibrillary acidic protein (GFAP)] in the brain cortex, hippocampus, striatum, midbrain, cerebellum, andpons Varolii 1, 12, 24, 120, and 168 h after a single X-ray irradiation session (dose of 0.25 Gy). Within the postirradiation period, manifestations of the behavioral activity of the animals were mostly suppressed, and the parameters related to the emotional state of the animals were influenced to a greater extent. The dynamics of the NCAM and GFAP contents were complex and dissimilar in the brain structures under study, but it was possible to observe some general regularities. Within early periods of time, 12 h after irradiation, the NCAM content increased in the cortex, hippocampus, and cerebellum. In these structures, it reached approximately 220, 170, and 150%, respectively, as compared with the control, while it dropped to about 40% in thepons Varolii. Changes in the GFAP content reached their maximum 24 h after irradiation; this index dropped to 29, 44, 34, and 67% in the striatum,pons Varolii, midbrain, and cerebellum, respectively, while it increased to 380% in the hippocampus. Later time intervals were characterized by smoother changes in the contents of the above neurospecific proteins. Seven days after irradiation, the NCAM content did not differ from initial values in the striatum and cerebellum and was higher than the control in the neocortex, hippocampus, and midbrain. Within this period, the GFAP level in the cerebellum and midbrain was relatively normalized, but it increased in the hippocampus and decreased in the pons and striatum. Therefore, the greatest postirradiation shifts in the NCAM and GFAP levels were observed in the structures of the limbic system, and this can be correlated with the data on testing the rats in an open field. Kluwer Academic/Plenum Publishers, 2000 neurospecific proteins nationallicence NCAM nationallicence GFAP nationallicence X-ray irradiation nationallicence behavior in an open-field test nationallicence Leshchinskaya I. Dnepropetrovsk State University, Ukraine aut Douka T. Dnepropetrovsk State University, Ukraine aut Chernaya V. Dnepropetrovsk State University, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/1(2000-01-01), 17-22 0090-2977 32:1<17 2000 32 11062 https://doi.org/10.1007/BF02515163 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02515163 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Leshchinskaya I. Dnepropetrovsk State University, Ukraine aut NATIONALLICENCE 700 1- Douka T. Dnepropetrovsk State University, Ukraine aut NATIONALLICENCE 700 1- Chernaya V. Dnepropetrovsk State University, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/1(2000-01-01), 17-22 0090-2977 32:1<17 2000 32 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer