caa a22 4500 475835352 CHVBK 20180406123851.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/BF02515161 doi (NATIONALLICENCE)springer-10.1007/BF02515161 Neuropharmacological profile of a high-affinity ligand of 5-HT1A receptors, 4-phenyl-1-[4-(2-naphtalimido)butyl]-piperazine [Elektronische Daten] [T. Karaseva, B. Lobasyuk, S. Soboleva, E. Kostenko, S. Andronati] The neuropharmacological profile of 4-phenyl-1-[4-(2-naphtalimido)butyl]-piperazine (PNBP), a compound that possesses a high affinity for the serotonin receptors of 1A-type (5-HT1A) and lacks an anxiolytic action, has been studied. Intracerebral administration of PNBP to rats through implanted cannulae into the hippocampal region resulted in no substantial behavioral changes during "open field” and "conflict situation” tests, as compared with those of control animals. At the same time, the behavioral effects of intraperitoneal administration of 10 mg/kg buspirone were completely abolished if buspirone had been jointly administered with 10 mg/kg PNBP. Moreover, combined application of 0.3 mg/kg PNBP and 0.3 mg/kg 8-OH-DPAT, an agonist of 5-HT1A receptors, almost completely abolished the components of "serotonin syndrome” (prone position and stamping of the forepaws) in animals under study. These findings allowed us to conclude that PNBP has the properties of a competitive antagonist of buspirone and 8-OH-DPAT. Kluwer Academic/Plenum Publishers, 2000 anxiolytics nationallicence buspirone nationallicence serotonin receptors nationallicence "open field” and "conflict situation” tests nationallicence Karaseva T. Bogatskii Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine aut Lobasyuk B. Bogatskii Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine aut Soboleva S. Bogatskii Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine aut Kostenko E. Bogatskii Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine aut Andronati S. Bogatskii Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/1(2000-01-01), 8-11 0090-2977 32:1<8 2000 32 11062 https://doi.org/10.1007/BF02515161 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02515161 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karaseva T. Bogatskii Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine aut NATIONALLICENCE 700 1- Lobasyuk B. Bogatskii Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine aut NATIONALLICENCE 700 1- Soboleva S. Bogatskii Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine aut NATIONALLICENCE 700 1- Kostenko E. Bogatskii Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine aut NATIONALLICENCE 700 1- Andronati S. Bogatskii Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/1(2000-01-01), 8-11 0090-2977 32:1<8 2000 32 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer