caa a22 4500 475835395 CHVBK 20180406123851.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/BF02515168 doi (NATIONALLICENCE)springer-10.1007/BF02515168 Komissarov I. Donetsk State Medical University, Ukraine aut Activation of synaptic receptors and its allosteric regulation [Elektronische Daten] [I. Komissarov] This review considers activation of synaptic receptors (SR) as a process of transduction of the energy of interaction between an agonist (A) and an agonist-recognizing module (R) toward an ion-conducting module (channel,Ch) orG protein within respective complexes (ARCh orARG). The agonist provides functional and, in the case of metabotropic SR, spatial association of protein components in these complexes. Conformational transformations of the latter, which are sufficient for dissociation ofG protein into subunits or opening of an ion-conducting channel, sometimes need additional energy expenditure. The source for this energy can be interaction with one more ligand: guanosine-5′-triphosphate (in the case of metabotropic SR) or glycine (in case of NMDA receptors), which act as co-agonists. The activation of SR is regulated by their allosteric modulators, which affect either the kinetics of interaction between the agonist and receptor by changing the rate of dissociation with the agonist or the kinetics of conformational transitions of the components into the activated or desensitized state. Kluwer Academic/Plenum Publishers, 2000 ionotropic and metabotropic receptors nationallicence receptor-channel complexes nationallicence allosteric regulation nationallicence receptor modulators and modifiers nationallicence metaffinoid and metactoid modulators nationallicence Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/1(2000-01-01), 45-56 0090-2977 32:1<45 2000 32 11062 https://doi.org/10.1007/BF02515168 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02515168 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Komissarov I. Donetsk State Medical University, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/1(2000-01-01), 45-56 0090-2977 32:1<45 2000 32 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer