caa a22 4500 47583545X CHVBK 20180406123851.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1023/A:1010444117248 doi (NATIONALLICENCE)springer-10.1023/A:1010444117248 Modification of the State of Adrenergic Systems: Effects on Experimental Tumor Growth and Antitumor Activity of Chlofiden [Elektronische Daten] [A. Pous'kov, N. Sharykina, G. Pavlovskaya, L. Kirichok, T. Karatsuba] We studied the effects of treatments with adrenaline hydrochloride, obsidan (a β-adrenoblocker), melipramine (an inhibitor of monoamine uptake by neurons), and reserpine (a sympatholytic drug) on tumor growth (Pliss' lymphosarcoma in rats) and on the antitumor activity of a novel cytostatic drug, chlofiden. We found that adrenaline and reserpine enhanced the antitumor effect of chlofiden. Isolated applications of adrenaline and melipramine exerted slight antitumor effects, while after reserpine treatment there was a trend toward stimulation of tumor growth. Under the conditions of the model used, obsidan demonstrated no noticeable antitumor activity and did not modify the antitumor effect of chlofiden. Possible mechanisms of the observed effects are discussed. Plenum Publishing Corporation, 2000 adrenergic systems nationallicence adrenaline nationallicence adrenoblockers nationallicence sympatholytics nationallicence tumor growth nationallicence cytostatics nationallicence Pous'kov A. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Sharykina N. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Pavlovskaya G. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Kirichok L. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Karatsuba T. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/6(2000-11-01), 390-394 0090-2977 32:6<390 2000 32 11062 https://doi.org/10.1023/A:1010444117248 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1010444117248 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pous'kov A. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Sharykina N. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Pavlovskaya G. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Kirichok L. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Karatsuba T. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/6(2000-11-01), 390-394 0090-2977 32:6<390 2000 32 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer