caa a22 4500 475835549 CHVBK 20180406123851.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1023/A:1010496101318 doi (NATIONALLICENCE)springer-10.1023/A:1010496101318 Litvinova L. Danilevskii Institute for Problems of Endocrine Pathology, Academy of Medical Sciences of Ukraine, Khar'kov, Ukraine aut Role of Non-Aromatizable Androgens in the Central Control of Pubertation of Female Rats [Elektronische Daten] [L. Litvinova] In 30-postnatal day-old rat females we created a decreased or increased level of 5α-reduced (non-aromatizable) androgens, using injections of an inhibitor of 5α-reductase or exogenous dihydrotestosterone, respectively. In these animals, we measured the levels of noradrenaline (NA) and serotonin (5-HT) in the hypothalamus, those of gonadotropins in the hypophysis, and testosterone and estradiol in the blood plasma; the process of pubertation was also monitored. In rats with a deficiency of non-aromatizable androgens, the NA level increased, while that of 5-HT dropped. In animals with an excess of these hormones, the 5-HT level remained stable against the background of a certain increase in the NA level. In the first group of animals, the estradiol level in the blood increased by a factor of 3, while the testosterone level increased insignificantly. The beginning of pubertation in these animals was not shifted, while the first ovulation occurred somewhat earlier, as compared with the control. In the second group of rats, treatment with exogenous dihydrotestosterone accelerated the beginning of pubertation, but the interval between opening of the vagina and first ovulation even somewhat increased. The neurotransmitter hypothalamic mechanisms mediating acceleration of an initial phase of the female pubertation and retardation of its final phase under the influence of non-aromatizable androgens are discussed. Plenum Publishing Corporation, 2000 pubertation of females nationallicence catecholamines nationallicence hypothalamus nationallicence androgens nationallicence estrogens nationallicence gonadotropins nationallicence Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/6(2000-11-01), 395-399 0090-2977 32:6<395 2000 32 11062 https://doi.org/10.1023/A:1010496101318 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1010496101318 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Litvinova L. Danilevskii Institute for Problems of Endocrine Pathology, Academy of Medical Sciences of Ukraine, Khar'kov, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/6(2000-11-01), 395-399 0090-2977 32:6<395 2000 32 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer