caa a22 4500 475836227 CHVBK 20180406123853.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1023/A:1005264326533 doi (NATIONALLICENCE)springer-10.1023/A:1005264326533 The Lateral Hypothalamic Area: Peculiarities of Aging and the Effect of Chronic Electrical Stimulation on the Lifespan in Rats [Elektronische Daten] [V. Frolkis, Yu. Rushkevich, T. Dubilei, S. Mikhal'skii, V. Gerasimov] Age-related morphological and functional changes in the lateral hypothalamic area (LHA) were studied in experiments on young adult (6-8 months) and old (26-28 months) male Wistar rats. It was found that during aging the neuronal density in the LHA decreased, and significant qualitative destructive and dystrophic changes in the neuronal population developed. The background impulse activity of LHA neuronal units, the mass background electrical activity recorded from this structure, and the Na+, K+-ATPase activity decreased during aging. In old rats, the rate of LHA self-stimulation was lower, and the range of reinforcing current amplitudes, which provided self-stimulation intensity close to the maximum, was narrower than in adult animals. Chronic electrical LHA stimulation in old rats ensured an increase in the lifespan and maximum life expectancy in these animals. In addition, the lifespan positively correlated with the duration of LHA stimulation. It is concluded that lowering of the functional activity of the LHA neural systems is one of the substantial aspects of the aging process, and activation of this structure in old animals by its chronic electrical stimulation can exert a geroprotective effect. Plenum Publishing Corporation, 2000 lateral hypothalamic area nationallicence aging nationallicence increase of lifespan nationallicence Frolkis V. Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Rushkevich Yu Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Dubilei T. Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Mikhal'skii S. Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Gerasimov V. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/4(2000-07-01), 276-282 0090-2977 32:4<276 2000 32 11062 https://doi.org/10.1023/A:1005264326533 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1005264326533 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Frolkis V. Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Rushkevich Yu Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Dubilei T. Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Mikhal'skii S. Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Gerasimov V. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/4(2000-07-01), 276-282 0090-2977 32:4<276 2000 32 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer