caa a22 4500 475836332 CHVBK 20180406123854.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1023/A:1010371322632 doi (NATIONALLICENCE)springer-10.1023/A:1010371322632 Changes in the NCAM Level in the Brain Structures of Stressed Rats and Recovery of This Level by Haloperidol Treatment [Elektronische Daten] [G. Ushakova, V. Berezin, P. Nerush] Rats were subjected to a fractionated stress procedure (randomized application of repeated and combined acoustic, light-flash, and nociceptive stimulations, 1 h daily over 1 month). After this session, the NCAM levels in the striatum, mesencephalon, and neocortex increased by 57-74%. Single injections of 1.5 mg/kg haloperidol 40 min to 24 h before sacrificing decreased the NCAM levels in all the above structures practically to control values. Injections of an anticonvulsant, sodium valproate (200 mg/kg), did not change the NCAM levels increased after stressing. We conclude that under stress conditions NCAM are involved in plastic transformations of the synaptic structures, mostly in populations of the excitatory neurons. This is not accompanied by qualitative modifications in the NCAM form composition. Plenum Publishing Corporation, 2000 NCAM nationallicence stress nationallicence haloperidol nationallicence valproate nationallicence immunoblotting nationallicence Ushakova G. Dnepropetrovsk Division of International Center for Molecular Physiology, National Academy of Sciences of Ukraine, Ukraine aut Berezin V. Protein Laboratory, Copenhagen University, Denmark aut Nerush P. Dnepropetrovsk State Medical Academy, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/5(2000-09-01), 321-325 0090-2977 32:5<321 2000 32 11062 https://doi.org/10.1023/A:1010371322632 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1010371322632 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ushakova G. Dnepropetrovsk Division of International Center for Molecular Physiology, National Academy of Sciences of Ukraine, Ukraine aut NATIONALLICENCE 700 1- Berezin V. Protein Laboratory, Copenhagen University, Denmark aut NATIONALLICENCE 700 1- Nerush P. Dnepropetrovsk State Medical Academy, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/5(2000-09-01), 321-325 0090-2977 32:5<321 2000 32 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer