caa a22 4500 475836375 CHVBK 20180406123854.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/BF02515177 doi (NATIONALLICENCE)springer-10.1007/BF02515177 Effects of modulation of the cholinergic system activity on the experimental tumor growth and antitumor activity of chlofiden [Elektronische Daten] [A. Pous'kov, N. Sharykina, G. Pavlovskaya, T. Karatsuba] We studied the influence of an anticholinesterase agent, proserine, and an m-cholinoblocker, atropine, on the growth of Pliss lymphosarcoma in rats and on the antitumor activity of a cytotoxic drug, chlofiden. It has been demonstrated that proserine stimulates tumor growth and decreases the antitumor efficacy of chlofiden. Injections of atropine evoked opposite effects: inhibition of the tumor growth and an increase in the, antitumor activity of chlofiden. Possible mechanisms of the above effects are discussed. Kluwer Academic/Plenum Publishers, 2000 cholinergic system nationallicence cholinesterase nationallicence m-cholinoblockers nationallicence tumor growth nationallicence Pliss lymphosarcoma nationallicence Pous'kov A. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Sharykina N. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Pavlovskaya G. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Karatsuba T. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/2(2000-03-01), 106-110 0090-2977 32:2<106 2000 32 11062 https://doi.org/10.1007/BF02515177 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02515177 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pous'kov A. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Sharykina N. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Pavlovskaya G. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Karatsuba T. Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/2(2000-03-01), 106-110 0090-2977 32:2<106 2000 32 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer