caa a22 4500 475836391 CHVBK 20180406123854.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/BF02515172 doi (NATIONALLICENCE)springer-10.1007/BF02515172 Electrical bistability in a neuron model with monostable dendritic and axosomatic membranes [Elektronische Daten] [S. Korogod, I. Kulagina] In a two-compartment mathematical model, we studied the reason for and conditions of manifestation of electrical bistability in a neuron composed of monostable parts. One compartment of the model simulated the dendrites; their membrane was monostable at high depolarization and characterized by an N-shaped steady current-voltage (I-V) characteristic endowed by inward synaptic current through voltage-dependent channels sensitive to N-methyl-D-aspartate (NMDA). Another compartment simulated the axosomatic region with a positively sloped linearizedI-V characteristic of the membrane monostable at the resting membrane potential. For the whole cell, bistability was obvious at a subcritical intensity of NMDA activation; the reason was the current directed from the more depolarized dendritic region into the somatic region, and the necessary condition was that the above somatopetal core current must exceed the net inward transmembrane current (the latter was the sum of the inward synaptic and outward passive extrasynaptic currents) of the dendritic compartment. This relation essentially depended on the size of the dendrites. Kluwer Academic/Plenum Publishers, 2000 neuron models nationallicence electrical bistability nationallicence NMDA conductance nationallicence electrical properties of dendrites nationallicence Korogod S. Dnepropetrovsk Division of International Center for Molecular Physiology, National Academy of Sciences of Ukraine, Ukraine aut Kulagina I. Dnepropetrovsk Division of International Center for Molecular Physiology, National Academy of Sciences of Ukraine, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/2(2000-03-01), 73-76 0090-2977 32:2<73 2000 32 11062 https://doi.org/10.1007/BF02515172 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02515172 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Korogod S. Dnepropetrovsk Division of International Center for Molecular Physiology, National Academy of Sciences of Ukraine, Ukraine aut NATIONALLICENCE 700 1- Kulagina I. Dnepropetrovsk Division of International Center for Molecular Physiology, National Academy of Sciences of Ukraine, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/2(2000-03-01), 73-76 0090-2977 32:2<73 2000 32 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer