caa a22 4500 475836448 CHVBK 20180406123854.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/BF02515178 doi (NATIONALLICENCE)springer-10.1007/BF02515178 Calpain as one of the calcium signal mediators in the cell [Elektronische Daten] [T. Kastrykina, M. Malysheva] This review gathers together the available information on the structural and functional properties of an intracellular calcium-dependent protease, calpain, and its inhibitors and activators. Changes in the ideas about the mechanism of enzyme activation, its interaction with substrate, and regulation of functions are considered in light of recently obtained information. The multi-faceted participation of calpain in the realization of one of the most important physiological function connected with calcium signalization is demonstrated with concrete example (in particular, in the case of a memory model, based on long-term synaptic potentiation). Kluwer Academic/Plenum Publishers, 2000 calpain nationallicence calpastatin nationallicence calcium signal nationallicence long-term potentiation nationallicence memory nationallicence Kastrykina T. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine aut Malysheva M. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/2(2000-03-01), 111-123 0090-2977 32:2<111 2000 32 11062 https://doi.org/10.1007/BF02515178 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02515178 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kastrykina T. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Malysheva M. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/2(2000-03-01), 111-123 0090-2977 32:2<111 2000 32 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer