caa a22 4500 475836456 CHVBK 20180406123854.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/BF02515171 doi (NATIONALLICENCE)springer-10.1007/BF02515171 Polyasnyi V. Ministry of Public Health of Ukraine, Odessa State Medical University, Ukraine aut Modifications of NMDA-induced convulsive reactions in diazepam-tolerant rats [Elektronische Daten] [V. Polyasnyi] In acute experiments on rats, the mean ED50 values of intraventricularly injected NMDA for evoking clonic seizures and tonic extension of the forelimbs were 0.69 and 11.36 μg per animal, respectively. When these indices were measured under conditions of the development of tolerance to diazepam (2 weeks from the abolition of a 3-week-long diazepam treatment, 0.5 mg/kg, i.p.), the dropped to 0.30 and 2.66 μg per animal, respectively. The results show that in diazepam-tolerant rats the sensitivity to the epileptogenic influence of NMDA increases, and such an increase is more significant with respect to tonic seizure manifestations. Kluwer Academic/Plenum Publishers, 2000 seizure reactions nationallicence excitatory amino acids nationallicence NMDA nationallicence benzodiazepines nationallicence tolerance nationallicence Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/2(2000-03-01), 70-72 0090-2977 32:2<70 2000 32 11062 https://doi.org/10.1007/BF02515171 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02515171 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Polyasnyi V. Ministry of Public Health of Ukraine, Odessa State Medical University, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 32/2(2000-03-01), 70-72 0090-2977 32:2<70 2000 32 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer