caa a22 4500 47584355X CHVBK 20180406123907.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1023/A:1027243713372 doi (NATIONALLICENCE)springer-10.1023/A:1027243713372 Syntheses of 1,2,4-triazolo[4,3- c ]pteridines. Potential substrates for xanthine oxidase [Elektronische Daten] [Władysław Kraus, Henk van der Plas] A synthetic route for the preparation of 9-phenyl-1,2,4-triazolo[4,3-c]pteridines 8 is described. Their reactivities towards xanthine oxidase from Arthrobacter M-4 are determined and compared with the pteridine derivatives 6-phenylpteridin-4[3H]-thione 5, 6-phenyl-4-thiomethylpteridine 6, 4-hydrazino-6-phenylpteridine 7, 3-N-methyl-6-phenylpteridin-4[3H]-thione 19, 4-amino-6-phenylpteridine 22 and 1-N-methyl-6-phenylpteridin-4[1H]-one 24, in order to inspect a possible influence of pyrimidine ring substitution pattern on their interaction with the bacterial enzyme. It has been suggested that a planar structure of the pteridine moiety and the substituents could be an important factor that so far has been overlooked when considering the enzyme activity. Some literature data are also discussed in view of revision of structure assignment of the compounds 12, 14, and 17. Kluwer Academic Publishers, 2000 bacterial xanthine oxidase nationallicence enzymatic oxidation nationallicence enzyme inhibition nationallicence pteridine derivatives nationallicence 1,2,4-triazolo[4,3- c ]pteridine synthesis nationallicence s -triazolopyrimidine moiety nationallicence Kraus Władysław Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek Str., PL 30-239, Kraków, Poland aut van der Plas Henk Department of Organic Chemistry, Wageningen Agricultural University, PO Box 9101, NL 6700 HB, Wageningen, The Netherlands aut Topics in Catalysis Kluwer Academic Publishers-Plenum Publishers 11-12/1-4(2000-04-01), 409-417 1022-5528 11-12:1-4<409 2000 11-12 11244 https://doi.org/10.1023/A:1027243713372 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1027243713372 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kraus Władysław Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek Str., PL 30-239, Kraków, Poland aut NATIONALLICENCE 700 1- van der Plas Henk Department of Organic Chemistry, Wageningen Agricultural University, PO Box 9101, NL 6700 HB, Wageningen, The Netherlands aut NATIONALLICENCE 773 0- Topics in Catalysis Kluwer Academic Publishers-Plenum Publishers 11-12/1-4(2000-04-01), 409-417 1022-5528 11-12:1-4<409 2000 11-12 11244 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer