caa a22 4500 475844874 CHVBK 20180406123911.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s000180050495 doi (NATIONALLICENCE)springer-10.1007/s000180050495 Matrix metalloproteinases in tumor invasion [Elektronische Daten] [N. Johansson, M. Ahonen, V.-M. Kähäri *] Abstract.: Controlled degradation of extracellular matrix (ECM) is essential for the growth, invasion, and metastasis of malignant tumors, and for tumor-induced angiogenesis. Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases collectively capable of degrading essentially all ECM components and they apparently play an important role in all these aspects of tumor development. Furthermore, recent evidence suggests that MMPs also play a role in tumor cell survival. In this review, we discuss the current concept concerning the role of MMPs and their inhibitors in tumor invasion, as a basis for prognosis and targeted therapeutic intervention in cancer. Birkhäuser Verlag Basel,, 2000 Key words. Squamous cell carcinoma nationallicence invasion nationallicence matrix nationallicence metalloproteinase nationallicence Johansson N. Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku (Finland), FI aut Ahonen M. MediCity Research Laboratory and Department of Medical Biochemistry, University of Turku, Tykistökatu 6A 20520 Turku (Finland), Fax +358 2 333 7000, e-mail: veli-matti.kahari@utu.fi, FI aut Kähäri * V.-M MediCity Research Laboratory and Department of Medical Biochemistry, University of Turku, Tykistökatu 6A 20520 Turku (Finland), Fax +358 2 333 7000, e-mail: veli-matti.kahari@utu.fi, FI aut https://doi.org/10.1007/s000180050495 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s000180050495 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Johansson N. Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku (Finland), FI aut NATIONALLICENCE 700 1- Ahonen M. MediCity Research Laboratory and Department of Medical Biochemistry, University of Turku, Tykistökatu 6A 20520 Turku (Finland), Fax +358 2 333 7000, e-mail: veli-matti.kahari@utu.fi, FI aut NATIONALLICENCE 700 1- Kähäri * V.-M MediCity Research Laboratory and Department of Medical Biochemistry, University of Turku, Tykistökatu 6A 20520 Turku (Finland), Fax +358 2 333 7000, e-mail: veli-matti.kahari@utu.fi, FI aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer