caa a22 4500 475844882 CHVBK 20180406123911.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s000180050496 doi (NATIONALLICENCE)springer-10.1007/s000180050496 Adhesion receptors and cell invasion: mechanisms of integrin-guided degradation of extracellular matrix [Elektronische Daten] [J. Ivaska, J. Heino*] Abstract.: The integrins are a large family of heterodimeric cell adhesion receptors mediating cell-matrix and cell-cell adhesion. They seem to play a central role in cell migration and invasion and are therefore essential in processes such as healing of tissue injuries and the progression of human cancer. Integrins function in cell invasion by mediating cell movement on matrix molecules and also by regulating the expression of matrix-degrading enzymes, namely the matrix metalloproteinases. Here we review recent findings on the mechanisms by which integrins regulate matrix degradation. A novel, multistep model of integrin-guided collagen degradation is proposed. Birkhäuser Verlag Basel,, 2000 Key words. Integrins nationallicence cell adhesion nationallicence signaling nationallicence matrix metalloproteinases nationallicence cell invasion nationallicence collagen nationallicence Ivaska J. MediCity Research Laboratory and the Department of Medical Biochemistry, University of Turku, FIN-20520 Turku (Finland), Fax +358 2333 7000, e-mail: jyrki.heino@utu.fi, FI aut Heino* J. MediCity Research Laboratory and the Department of Medical Biochemistry, University of Turku, FIN-20520 Turku (Finland), Fax +358 2333 7000, e-mail: jyrki.heino@utu.fi, FI aut https://doi.org/10.1007/s000180050496 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s000180050496 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ivaska J. MediCity Research Laboratory and the Department of Medical Biochemistry, University of Turku, FIN-20520 Turku (Finland), Fax +358 2333 7000, e-mail: jyrki.heino@utu.fi, FI aut NATIONALLICENCE 700 1- Heino* J. MediCity Research Laboratory and the Department of Medical Biochemistry, University of Turku, FIN-20520 Turku (Finland), Fax +358 2333 7000, e-mail: jyrki.heino@utu.fi, FI aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer