caa a22 4500 475844904 CHVBK 20180406123911.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s000180050497 doi (NATIONALLICENCE)springer-10.1007/s000180050497 The plasminogen activation system in tumor growth, invasion, and metastasis [Elektronische Daten] [P. A. Andreasen*, R. Egelund, H. H. Petersen] Abstract.: Generation of the serine proteinase plasmin from the extracellular zymogen plasminogen can be catalyzed by either of two other serine proteinases, the urokinase- and tissue-type plasminogen activators (uPA and tPA). The plasminogen activation system also includes the serpins PAI-1 and PAI-2, and the uPA receptor (uPAR). Many findings, gathered over several decades, strongly suggest an important and causal role for uPA-catalyzed plasmin generation in cancer cell invasion through the extracellular matrix. Recent evidence suggests that the uPA system is also involved in cancer cell-directed tissue remodeling. Moreover, the system also supports cell migration and invasion by plasmin-independent mechanisms, including multiple interactions between uPA, uPAR, PAI-1, extracellular matrix proteins, integrins, endocytosis receptors, and growth factors. These interactions seem to allow temporal and spatial reorganizations of the system during cell migration and a selective degradation of extracellular matrix proteins during invasion. The increased knowledge about the plasminogen activation system may allow utilization of its components as targets for anti-invasive therapy. Birkhäuser Verlag Basel,, 2000 Key words. Serine proteinases nationallicence serpins nationallicence integrins nationallicence cell migration nationallicence anti-invasive therapy nationallicence Andreasen* P. A. Cellular Protein Science Laboratory, Department of Molecular and Structural Biology, Aarhus University, 10C Gustav Wied's Vej, 8000 Aarhus C (Denmark), Fax +45 8612 3178, e-mail: pa@mbio.aau.dk, DK aut Egelund R. Cellular Protein Science Laboratory, Department of Molecular and Structural Biology, Aarhus University, 10C Gustav Wied's Vej, 8000 Aarhus C (Denmark), Fax +45 8612 3178, e-mail: pa@mbio.aau.dk, DK aut Petersen H. H. Cellular Protein Science Laboratory, Department of Molecular and Structural Biology, Aarhus University, 10C Gustav Wied's Vej, 8000 Aarhus C (Denmark), Fax +45 8612 3178, e-mail: pa@mbio.aau.dk, DK aut https://doi.org/10.1007/s000180050497 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s000180050497 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andreasen* P. A. Cellular Protein Science Laboratory, Department of Molecular and Structural Biology, Aarhus University, 10C Gustav Wied's Vej, 8000 Aarhus C (Denmark), Fax +45 8612 3178, e-mail: pa@mbio.aau.dk, DK aut NATIONALLICENCE 700 1- Egelund R. Cellular Protein Science Laboratory, Department of Molecular and Structural Biology, Aarhus University, 10C Gustav Wied's Vej, 8000 Aarhus C (Denmark), Fax +45 8612 3178, e-mail: pa@mbio.aau.dk, DK aut NATIONALLICENCE 700 1- Petersen H. H. Cellular Protein Science Laboratory, Department of Molecular and Structural Biology, Aarhus University, 10C Gustav Wied's Vej, 8000 Aarhus C (Denmark), Fax +45 8612 3178, e-mail: pa@mbio.aau.dk, DK aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer