caa a22 4500 475844912 CHVBK 20180406123911.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s000180050499 doi (NATIONALLICENCE)springer-10.1007/s000180050499 The Ras family of GTPases in cancer cell invasion [Elektronische Daten] [R. Hernández-Alcoceba, L. del Peso, J. C. Lacal*] Abstract.: The ability of tumoral cells to invade surrounding tissues is a prerequisite for metastasis. This is the most life-threatening event of tumor progression, and so research is intensely focused on elucidating the mechanisms responsible for invasion and metastasis. The Ras superfamily of GTPases comprises several subfamilies of small GTP-binding proteins whose functions include the control of proliferation, differentiation, and apoptosis, as well as cytoskeleton organization. The development of metastasis is a multistep process that requires coordinated activation of proliferation, motility, changes in normal cell-to-cell and cell-to-substrate contacts, degradation of extracellular matrix, inhibition of apoptosis, and adaptation to an inappropriate tissue environment. Several members of the Ras superfamily of proteins have been implicated in these processes. The present review summarizes the current knowledge in this field. Birkhäuser Verlag Basel,, 2000 Key words. Ras nationallicence Rho nationallicence metastasis nationallicence invasion nationallicence cytoskeleton nationallicence adhesion nationallicence apoptosis nationallicence Hernández-Alcoceba R. Department of Internal Medicine and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor (Michigan 48109, USA), AL aut del Peso L. Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor (Michigan 48109, USA), AL aut Lacal* J. C. Instituto de Investigaciones Biomédicas, c/Arturo Duperier, 4., E-28029 Madrid (Spain), Fax +3491 585 4606, e-mail: jclacal@iib.uam.es, ES aut https://doi.org/10.1007/s000180050499 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s000180050499 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hernández-Alcoceba R. Department of Internal Medicine and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor (Michigan 48109, USA), AL aut NATIONALLICENCE 700 1- del Peso L. Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor (Michigan 48109, USA), AL aut NATIONALLICENCE 700 1- Lacal* J. C. Instituto de Investigaciones Biomédicas, c/Arturo Duperier, 4., E-28029 Madrid (Spain), Fax +3491 585 4606, e-mail: jclacal@iib.uam.es, ES aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer