caa a22 4500 475844920 CHVBK 20180406123911.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s000180050504 doi (NATIONALLICENCE)springer-10.1007/s000180050504 Loperamide: novel effects on capacitative calcium influx [Elektronische Daten] [J. W. Daly, J. Harper] Abstract.: Loperamide is a widely used antidiarrheal that primarily acts at nanomolar concentrations through activation of opioid receptors in the gastrointestinal tract. At somewhat higher concentrations, loperamide blocks calmodulin activity, calcium channels, N-methyl-d-aspartate-receptor channels, and maitotoxin-elicited calcium influx. Loperamide at micromolar concentrations has now been shown to have a remarkable stimulatory effect on the capacitative calcium influx that is triggered in many cells by depletion of the inositol-trisphosphate-sensitive stores of calcium in the endoplasmic reticulum. The mechanism whereby loperamide enhances levels of intracellular calcium elevated by capacitative calcium influx is, as yet, undefined. Birkhäuser Verlag Basel,, 1999 Key words. Loperamide nationallicence calcium channels nationallicence calcium stores nationallicence maitotoxin nationallicence inositol trisphosphate nationallicence thapsigargin nationallicence ATP nationallicence Daly J. W. Laboratory of Bioorganic Chemistry, Bldg 8, Rm 1A17, National Institutes of Health Bethesda (Maryland 20892, USA), Fax +1 301 402 0008, e-mail: johnd@intra.niddk.nih.gov, US aut Harper J. Laboratory of Bioorganic Chemistry, Bldg 8, Rm 1A17, National Institutes of Health Bethesda (Maryland 20892, USA), Fax +1 301 402 0008, e-mail: johnd@intra.niddk.nih.gov, US aut https://doi.org/10.1007/s000180050504 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s000180050504 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Daly J. W. Laboratory of Bioorganic Chemistry, Bldg 8, Rm 1A17, National Institutes of Health Bethesda (Maryland 20892, USA), Fax +1 301 402 0008, e-mail: johnd@intra.niddk.nih.gov, US aut NATIONALLICENCE 700 1- Harper J. Laboratory of Bioorganic Chemistry, Bldg 8, Rm 1A17, National Institutes of Health Bethesda (Maryland 20892, USA), Fax +1 301 402 0008, e-mail: johnd@intra.niddk.nih.gov, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer