caa a22 4500 475844939 CHVBK 20180406123911.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s000180050500 doi (NATIONALLICENCE)springer-10.1007/s000180050500 Cellular turnover and extracellular matrix remodeling in female reproductive tissues: functions of metalloproteinases and their inhibitors [Elektronische Daten] [J. E. Fata, A. T.-V. Ho, K. J. Leco, R. A. Moorehead, R. Khokha*] Abstract.: Female reproductive tissues possess a unique ability to accommodate a remarkable amount of cell turnover and extracellular matrix (ECM) remodeling following puberty. Cellular structures within ovary, uterus, and mammary tissue not only change cyclically in response to ovarian hormones but also undergo differentiation during pregnancy, and eventually revert to that resembling the pre-pregnant stage. Cell proliferation, apoptosis, invasion, and differentiation are integral cellular processes that are precisely regulated in reproductive tissues, but become dysregulated in pathologies such as cancer. Explicit reorganization of ECM and basement membranes is also critical to preserve the form and function of these tissues. Here we review the evidence that coordinated spatiotemporal expression patterns of matrix metalloproteinase (MMP) genes and their tissue inhibitors (TIMPs) are important in cell and ECM turnover of the ovary, uterus, and mammary tissues. We discuss how perturbation in these gene families may impact the biology of these reproductive tissues and the factors implicated in the control of MMP and TIMP gene expression. The observed trends in MMP and TIMP expression involved in ovarian and mammary carcinomas are also presented. Birkhäuser Verlag Basel,, 2000 Key words. TIMPs nationallicence MMPs nationallicence ECM nationallicence ovary nationallicence uterus nationallicence mammary tissue nationallicence Fata J. E. Department of Medical Biophysics, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, M5G 2M9 (Canada), Fax +1 416 946 2984, e-mail: rkhokha@oci.utoronto.ca, CA aut Ho A. T.-V Department of Medical Biophysics, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, M5G 2M9 (Canada), Fax +1 416 946 2984, e-mail: rkhokha@oci.utoronto.ca, CA aut Leco K. J. Department of Medical Biophysics, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, M5G 2M9 (Canada), Fax +1 416 946 2984, e-mail: rkhokha@oci.utoronto.ca, CA aut Moorehead R. A. Department of Medical Biophysics, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, M5G 2M9 (Canada), Fax +1 416 946 2984, e-mail: rkhokha@oci.utoronto.ca, CA aut Khokha* R. Department of Medical Biophysics, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, M5G 2M9 (Canada), Fax +1 416 946 2984, e-mail: rkhokha@oci.utoronto.ca, CA aut https://doi.org/10.1007/s000180050500 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s000180050500 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fata J. E. Department of Medical Biophysics, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, M5G 2M9 (Canada), Fax +1 416 946 2984, e-mail: rkhokha@oci.utoronto.ca, CA aut NATIONALLICENCE 700 1- Ho A. T.-V Department of Medical Biophysics, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, M5G 2M9 (Canada), Fax +1 416 946 2984, e-mail: rkhokha@oci.utoronto.ca, CA aut NATIONALLICENCE 700 1- Leco K. J. Department of Medical Biophysics, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, M5G 2M9 (Canada), Fax +1 416 946 2984, e-mail: rkhokha@oci.utoronto.ca, CA aut NATIONALLICENCE 700 1- Moorehead R. A. Department of Medical Biophysics, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, M5G 2M9 (Canada), Fax +1 416 946 2984, e-mail: rkhokha@oci.utoronto.ca, CA aut NATIONALLICENCE 700 1- Khokha* R. Department of Medical Biophysics, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, M5G 2M9 (Canada), Fax +1 416 946 2984, e-mail: rkhokha@oci.utoronto.ca, CA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer