caa a22 4500 47584498X CHVBK 20180406123911.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/PL00000668 doi (NATIONALLICENCE)springer-10.1007/PL00000668 Schrauzer G. N. Biological Trace Element Research Institute, San Diego (California 92121, USA) and Department of Chemistry, University of California, San Diego, La Jolla (California 92034, USA), Fax +1 858 794 0212, e-mail: gschrauzer@ucsd.edu, US aut Anticarcinogenic effects of selenium [Elektronische Daten] [G. N. Schrauzer] Abstract.: Selenium (Se) exerts its anticarcinogenic effects by multiple mechanisms. In the physiological dosage range, Se appears to function as an antimutagenic agent, preventing the malignant transformation of normal cells and the activation of oncogenes. These protective effects of Se seem to be primarily associated with its presence in the glutathione peroxidases, which are known to protect DNA and other cellular components from damage by oxygen radicals. Selenoenzymes are also known to play roles in carcinogen metabolism, in the control of cell division, oxygen metabolism, detoxification processes, apoptosis induction and the functioning of the immune system. Other modes of action, either direct or indirect, may also be operative, such as the partial retransformation of tumor cells and the inactivation of oncogenes. However, the effects of Se in the physiological dosage range are not attributable to cytotoxicity, allowing Se to be defined as a genuine nutritional cancer-protecting agent. The anticarcinogenic effects of Se are counteracted by Se-antagonistic compounds and elements. For maximal utilization of its cancer-protective potential, Se supplementation should start early in life and be maintained over the entire lifespan. In addition, exposure to Se antagonists and carcinogenic risk factors should be minimized by appropriate dietary and lifestyle changes. Birkhäuser Verlag Basel,, 2000 Key words. Selenium nationallicence cancer nationallicence cancer prevention nationallicence selenium supplementation nationallicence selenium antagonists nationallicence https://doi.org/10.1007/PL00000668 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000668 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Schrauzer G. N. Biological Trace Element Research Institute, San Diego (California 92121, USA) and Department of Chemistry, University of California, San Diego, La Jolla (California 92034, USA), Fax +1 858 794 0212, e-mail: gschrauzer@ucsd.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer